Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SSX4 contributors: mct/npt - updated : 25-03-2009
HGNC name synovial sarcoma, X breakpoint 4
HGNC id 11338
Location Xp11.23      Physical location : 48.242.967 - 48.271.344
Synonym name cancer/testis antigen 5.4
Synonym symbol(s) MGC119056, MGC12411, SSX4A
DNA
TYPE like-sequence
STRUCTURE 9.82 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status tentative : very preliminary evidence
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1250 21.7 188 - Ayyoub (2005)
7 - 1114 17.8 153 - Ayyoub (2005)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   lowly
Reproductivemale systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cell lineage
cell lines several types of cancers, i.e. melanoma
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a domain related to the KRAB domain of zinc finger proteins at the N terminus
  • a highly acidic C terminus
  • HOMOLOGY
    interspecies homolog to C.elegans t22c1.5
    intraspecies homolog to Krüppel associated box,KRAB
    Homologene
    FAMILY
  • SSX family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • acting as a modulator of transcription
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    rarely implicated in translocation t(X;18) in synovial sarcoma
    tumoral     --over  
    in melanomas (Ayyoub 2005)
    Susceptibility
    Variant & Polymorphism
    Candidate gene existence of CD4+ T cells specific for multiple SSX4 derived sequences in circulating lymphocytes from melanoma patients (Ayyoub 2005)
    Marker
    Therapy target
    ANIMAL & CELL MODELS