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FLASH GENE
Symbol SSX3 contributors: mct/npt - updated : 25-03-2009
HGNC name synovial sarcoma, X breakpoint 3
HGNC id 11337
Location Xp11.23      Physical location : 48.205.862 - 48.216.142
Synonym name
  • synovial sarcoma, X breakpoint 3, isoform a
  • cancer/testis antigen 5.3
  • Synonym symbol(s) CT5.3, MGC119054, MGC14495, RP11-344N17.4,
    DNA
    TYPE functioning gene
    STRUCTURE 10.28 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC392458 X similar to spermine synthase; spermidine aminopropyltransferase LOC392459 X similar to CpG binding protein (Protein containing PHD finger and CXXC domain 1) LOC286404 Xp11.3 hypothetical gene supported by NM_006990; AB026542 LOC389851 X similar to Itchy homolog E3 ubiquitin protein ligase (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1) LOC347344 Xp11.3 similar to Zinc finger protein 81 (HFZ20) ZNF21 Xp11.23 zinc finger protein 21 (KOX 14) LOC389852 X similar to dJ54B20.3 (novel protein similar to lysozyme C (1,4-beta-N-acetylmuramidase)) FLJ20573 Xp11.3-p11.1 hypothetical zinc finger protein FLJ20573 SSX6 Xp11.2 synovial sarcoma, X breakpoint 6 psiSSX2 Xp11.2 SSX2 pseudogene LOC389853 X similar to dJ54B20.3 (novel protein similar to lysozyme C (1,4-beta-N-acetylmuramidase)) LOC392460 X similar to Ornithine aminotransferase, mitochondrial precursor (Ornithine--oxo-acid aminotransferase) psiSSX3 Xp11.2 SSX3 pseudogene SSX5 Xp11.2-p11.1 synovial sarcoma, X breakpoint 5 LOC392462 X similar to synovial sarcoma, X breakpoint 6 SSX1 Xp11.23-p11.22 synovial sarcoma, X breakpoint 1 psiSSX8 Xp11.2 psiSSX8 pseudogene SSX9 Xp11.23 synovial sarcoma, X breakpoint 9 psiSSX9 Xp11.2 SSX9 pseudogene SSX3 Xp11.2-p11.1 synovial sarcoma, X breakpoint 3 SSX4 Xp11.2-p11.1 synovial sarcoma, X breakpoint 4 SLC38A5 Xp11.23 solute carrier family 38, member 5 FTSJ1 Xp11.23 FtsJ homolog 1 (E. coli) PPN Xp11.23 likely ortholog of mouse porcupine homolog (Drosophila) EBP Xp11.23-p11.22 emopamil binding protein (sterol isomerase) OATL1 Xp11.23-p11.22 ornithine aminotransferase-like 1 RBM3 Xp11.23 RNA binding motif protein 3 MRPL32P1 Xq11.23 RNA binding motif protein 3 WDR13 Xp11.23 WD repeat domain 13 WAS Xp11.23-p11.22 Wiskott-Aldrich syndrome (eczema-thrombocytopenia) SUV39H1 Xp11.23 suppressor of variegation 3-9 homolog 1 (Drosophila) LOC392465 X similar to RIKEN cDNA 2010001H14 LOC389854 X similar to Acetyl-coenzyme A acyltransferase 2 GATA1 Xp11.23 GATA binding protein 1 (globin transcription factor 1) HDAC6 Xp11.23 histone deacetylase 6 ERAS Xpter-q26 ES cell expressed Ras PCSK1N Xp11.23 proprotein convertase subtilisin/kexin type 1 inhibitor TIMM17B Xp11.23 translocase of inner mitochondrial membrane 17 homolog B (yeast)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1290 21.57 188 - Gure (2002)
    8 - 825 19.33 170 - Gure (2002)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   lowly
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines several types of cancers, i.e. melanoma
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a domain related to the KRAB domain of zinc finger proteins at the N terminus
  • a highly acidic C terminus
  • HOMOLOGY
    interspecies homolog to C.elegans k02f6.6
    intraspecies homolog to Krüppel associated box,KRAB
    Homologene
    FAMILY
  • SSX family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • modulation of transcription
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS