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FLASH GENE
Symbol SSX2IP contributors: npt/ - updated : 24-12-2007
HGNC name synovial sarcoma, X breakpoint 2 interacting protein
HGNC id 16509
Corresponding disease
BSSX synovial sarcoma
Location 1p22.3      Physical location : 85.109.389 - 85.156.240
Synonym name
  • afadin- and alpha-actinin-binding protein
  • Afadin DIL domain-interacting protein
  • SSX2-interacting protein
  • Synonym symbol(s) KIAA0923, ADIP, FLJ10848, MGC75026
    DNA
    TYPE functioning gene
    STRUCTURE 46.58 kb     15 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ23033 1p22.3 hypothetical protein FLJ23033 PRKACB 1p36.1or protein kinase, cAMP-dependent, catalytic, beta LOC148418 1p22.3 dnaj-like protein LOC391051 1 similar to urate oxidase (EC 1.7.3.3) - baboon DLAD 1p31.1 similar to urate oxidase (EC 1.7.3.3) - baboon RPF1 1p22.3 similar to urate oxidase (EC 1.7.3.3) - baboon GNG5 1p22 guanine nucleotide binding protein (G protein), gamma 5 SPATA1 1p22.3 spermatogenesis associated 1 CTBS 1p22 chitobiase, di-N-acetyl- FLJ35487 1p22.3 hypothetical protein FLJ35487 SSX2IP 1p22 synovial sarcoma, X breakpoint 2 interacting protein EDG7 1p22.3-p31.1 endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7 MCOLN2 1p22 mucolipin 2 MCOLN3 1p22.3 mucolipin 3 NYD-SP29 1p22.3 testis development protein NYD-SP29 FLJ13815 1p22.3 hypothetical protein FLJ13815 gm117 1p22.3 gm117 BCL10 1p22 B-cell CLL/lymphoma 10 DDAH1 1p22 dimethylarginine dimethylaminohydrolase 1 CYR61 1p31.p22 cysteine-rich, angiogenic inducer, 61 FLJ20729 1p22.3 hypothetical protein FLJ20729 COL24A1 1p22.3-p22.2 collagen, type XXIV, alpha 1 KIAA1229 1p22.3 KIAA1229 protein CLCA2 1p31-p22 chloride channel, calcium activated, family member 2 CLCA1 1p31-p22 chloride channel, calcium activated, family member 1 CLCA4 1p31-p22 chloride channel, calcium activated, family member 4
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 5658 - 614 - Nousiainen (2006)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   predominantly
    Reproductivemale systemtestis  highly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver, brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ER retention motif
  • nuclear localization signal (NLS)
  • three coiled-coil domains
  • one P-loop motif
  • HOMOLOGY
    Homologene
    FAMILY
  • SSX family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    text colocalizes with afadin at adherens junctions (AJs) and was also detectable at the perinuclear regions, probably the Golgi complex
    basic FUNCTION
  • actin filament (F-actin)-binding protein associated with the cytoplasmic tail of nectin, a Ca(2+)-independent immunoglobulin-like cell-cell adhesion molecule
  • may be involved in organization of the actin cytoskeleton at cell-cell adherens junctions (AJs) through afadin and alpha-actinin
  • involved in vesicle trafficking from the Golgi to the endoplasmic reticulum and through the Golgi complex by interacting with the coatomer complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SSX2
  • binding alpha-actinin, an F-actin-bundling protein known to be indirectly associated with E-cadherin through its direct binding to alpha-catenin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BSSX
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in myeloid leukaemia cells.
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS