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FLASH GENE
Symbol SSX2IP contributors: mct - updated : 04-01-2017
HGNC name synovial sarcoma, X breakpoint 2 interacting protein
HGNC id 16509
Corresponding disease
BSSX synovial sarcoma
Location 1p22.3      Physical location : 85.109.389 - 85.156.240
Synonym name
  • afadin- and alpha-actinin-binding protein
  • Afadin DIL domain-interacting protein
  • SSX2-interacting protein
  • Synonym symbol(s) KIAA0923, ADIP, FLJ10848, MGC75026, hMsd1
    DNA
    TYPE functioning gene
    STRUCTURE 46.58 kb     15 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 5658 - 614 - Nousiainen (2006)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   predominantly
    Reproductivemale systemtestis  highly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver, brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ER retention motif
  • nuclear localization signal (NLS)
  • three coiled-coil domains
  • one P-loop motif
  • HOMOLOGY
    Homologene
    FAMILY
  • SSX family, MSD1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microfilament
    intracellular,nucleus
    text
  • colocalizes with afadin at adherens junctions (AJs) and was also detectable at the perinuclear regions, probably the Golgi complex
  • localizes to the basal body of primary cilia in human and murine ciliated cells
  • basic FUNCTION
  • actin filament (F-actin)-binding protein associated with the cytoplasmic tail of nectin, a Ca(2+)-independent immunoglobulin-like cell-cell adhesion molecule
  • may be involved in organization of the actin cytoskeleton at cell-cell adherens junctions (AJs) through afadin and alpha-actinin
  • involved in vesicle trafficking from the Golgi to the endoplasmic reticulum and through the Golgi complex by interacting with the coatomer complex
  • is a novel centrosome maturation and maintenance factor that is expressed at the onset of vertebrate development
  • preserves centrosome integrity and faithful mitosis during the rapid cleavage division of blastomeres and in somatic cells
  • centriolar satellite protein, playing a role in the assembly of primary cilia
  • is a novel targeting factor for ciliary membrane proteins cooperating with CEP290, the BBSome, and RAB8A
  • is delivered to the centrosome in a centriolar satellite-dependent manner and binds the microtubule-nucleator gamma-tubulin complex
  • is essential for ciliogenesis
  • SSX2IP-mediated microtubule anchoring is essential for proper centriole assembly and duplication
  • conserved spindle anchoring protein
  • the conserved WRAP73-SSX2IP complex plays a critical role in controlling proper spindle length and orientation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • WRAP73 formed a complex and partially colocalised with SSX2IP
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SSX2
  • binding alpha-actinin, an F-actin-bundling protein known to be indirectly associated with E-cadherin through its direct binding to alpha-catenin
  • SSX2IP mediates the activation of RAC1 through VAV2
  • WRAP73 interacts with the satellite proteins SSX2IP and PCM1 as well as the centriolar proximal end component CEP135
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BSSX
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in myeloid leukaemia cells.
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS