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FLASH GENE
Symbol SSX2 contributors: mct/npt - updated : 25-03-2009
HGNC name synovial sarcoma, X breakpoint 2
HGNC id 11336
Corresponding disease
BSSX synovial sarcoma
Location Xp11.22      Physical location : 52.725.945 - 52.790.617
Synonym name
  • cancer/testis antigen 5.2
  • sarcoma, synovial, X-chromosome-related 2
  • synovial sarcoma, X breakpoint 2, isoform b
  • Synonym symbol(s) SSX, HD21, HOM-MEL-40, MGC3884, MGC15364, MGC119055, CT5.2a, SSX2A
    DNA
    TYPE functioning gene
    STRUCTURE 10.31 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1466 25.04 223 - Wu (2006)
    8 - 1322 21.5 188 - Wu (2006)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   lowly
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines several types of cancers, i.e. melanoma, rhabdomyosarcoma and fibrosarcoma
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a domain related to the KRAB domain of zinc finger proteins, at the N terminus
  • a highly acidic C terminus
  • HOMOLOGY
    interspecies homolog to C.elegans K02F6.6
    intraspecies homolog to Krüppel associated box,KRAB
    Homologene
    FAMILY
  • cancer/testis antigens family
  • SSX family
  • CATEGORY transcription factor , antigen , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • acting as a modulator of transcription
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS immunity/defense
    text human tumor antigen MOM-MEL-40
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with polycomb group (PcG) proteins RING1 or BMI1
  • INTERACTION
    DNA binding to chromatin
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BSSX
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma (Wu 2006)
    tumoral fusion      
  • fused with SYT (SSXT) in synovial sarcoma with translocation t(X;18)(p11.2;q11.2) (see BSSX)
  • Susceptibility
    Variant & Polymorphism
    Candidate gene mRNA detect circulating HCC cells as adjuvant diagnostic tool and as indicators of recurrence and prognosis (Wu 2006)
    Marker
    Therapy target
    ANIMAL & CELL MODELS