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FLASH GENE
Symbol SSTR4 contributors: mct - updated : 10-09-2009
HGNC name somatostatin receptor 4
HGNC id 11333
Location 20p11.21      Physical location : 23.016.056 - 23.017.314
Synonym name G-protein coupled receptor
Synonym symbol(s) SS4R
DNA
TYPE functioning gene
STRUCTURE 1.26 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map pter - PCSK2 - SSTR4 - THBD - PYGB - cen
Physical map
ST13P 20p11.22 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene C20orf56 20 chromosome 20 open reading frame 56 FOXA2 20p11 forkhead box A2 KRT18P3 Xq21 keratin 18 pseudogene 3 CYB5P4 20p11.2 cytochrome b-5 pseudogene 4 SSTR4 20p11.2 somatostatin receptor 4 THBD 20p11.2 thrombomodulin C1QR1 20pter-p12-3 complement component 1, q subcomponent, receptor 1 LOC200261 20p11.22 hypothetical protein LOC200261 NXT1 20p12-p11.2 NTF2-like export factor 1 LOC149913 20p11.21 hypothetical LOC149913 ZNF336 20p12.3-p11.21 zinc finger protein 336 NAPB 20p12.3-p11.21 N-ethylmaleimide-sensitive factor attachment protein, beta CSTL1 20p11.21 cystatin-like 1 CST11 20p11.21 cystatin 11 CST8 20p11.22-p11.21 cystatin 8 (cystatin-related epididymal specific) IMAGE:4837709 20p11.21 cystatin pseudogene LOC128820 20p11.21 cystatin pseudogene CST9L 20p11.21 cystatin 9-like (mouse) bA218C14.3 20p11.21 cystatin 9 CST3 20p11.22-p11.21 cystatin C (amyloid angiopathy and cerebral hemorrhage) CST4 20p11.2 cystatin S CST1 20p11.2 cystatin SN CSTP2 20p11.2 cystatin pseudogene 2 CST2 20p11.2 cystatin SA CST5 20p11.21 cystatin D CSTP1 20p11.2 cystatin pseudogene 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 1258 42 388 - 1993 8483934
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainforebraincerebral cortex   Homo sapiens
 brainlimbic systemhippocampus   Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • C-tail having a role on physiological responses of the cells
  • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY signaling hormone , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in negative regulation of cell proliferation, G-protein signaling, coupled to cyclic nucleotide second messenger
  • playing a role in cell proliferation and modulation of signaling pathways
  • in an appropriate cellular environment, can functionally couple to the inhibition of adenylyl cyclase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerization between SSTR4/SSTR5
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in benign prostatic hyperplasia (BPH) and prostate cancer
    tumoral     --over  
    in T-leukaemia cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene useful targets for therapy during inflammatory diseases and malignancies affecting lymphocytes
    Marker
    Therapy target
    ANIMAL & CELL MODELS