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FLASH GENE
Symbol SSTR4 contributors: mct - updated : 10-03-2022
HGNC name somatostatin receptor 4
HGNC id 11333
Location 20p11.21      Physical location : 23.016.056 - 23.017.314
Synonym name G-protein coupled receptor
Synonym symbol(s) SS4R, SS-4-R, SS4-R,
DNA
TYPE functioning gene
STRUCTURE 1.26 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map pter - PCSK2 - SSTR4 - THBD - PYGB - cen
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 1258 42 388 - 1993 8483934
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainforebraincerebral cortex   Homo sapiens
 brainlimbic systemhippocampus   Homo sapiens
Olfactory (smell)olfactory bulb     Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • C-tail having a role on physiological responses of the cells
  • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY signaling hormone , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in negative regulation of cell proliferation, G-protein signaling, coupled to cyclic nucleotide second messenger
  • playing a role in cell proliferation and modulation of signaling pathways
  • in an appropriate cellular environment, can functionally couple to the inhibition of adenylyl cyclase
  • SSTR1 and SSTR4 are the most frequently expressed SSTR subtypes in breast cancer, and the cell cycle arrest was mediated by SSTR1/SSTR4 dimerization/activation
  • contributions of GRHL3, SSTR2 and SSTR4 receptors in olfactory processing
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerization between SSTR4/SSTR5
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DLG2 interacted with SSTR4 and affected the level of SSTR4 on cell membrane, which was associated with the ubiquitination
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in benign prostatic hyperplasia (BPH) and prostate cancer
    tumoral     --over  
    in T-leukaemia cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene useful targets for therapy during inflammatory diseases and malignancies affecting lymphocytes
    Marker
  • expression of somatostatin receptors is a marker of luminal breast tumors
  • Therapy target
    ANIMAL & CELL MODELS