Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SSRP1 contributors: npt/mct/shn - updated : 11-05-2015
HGNC name structure specific recognition protein 1
HGNC id 11327
Location 11q12.1      Physical location : 57.093.459 - 57.103.351
Synonym name
  • FACT 80 kDa subunit
  • FACT complex subunit SSRP1
  • FACTp80
  • chromatin-specific transcription elongation factor 80 kDa subunit
  • cisplatin-DNA SSRP
  • facilitates chromatin remodeling 80 kDa subunit
  • facilitates chromatin transcription complex 80 kDa subunit
  • facilitates chromatin transcription complex subunit SSRP1
  • hSSRP1
  • high mobility group box
  • recombination signal sequence recognition protein 1
  • structure-specific recognition protein 1
  • Synonym symbol(s) FACT80, FACT, T160, FACTp80
    DNA
    TYPE functioning gene
    STRUCTURE 9.89 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D11S4459 - D11S1357 - SSRP1 - D11S1777 - D11S4953 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 2825 - 709 - 2002 12374749
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately Homo sapiens
    Digestiveintestinesmall intestinejejunum lowly Homo sapiens
     intestinesmall intestineileum lowly Homo sapiens
     liver   lowly Homo sapiens
    Lymphoid/Immunespleen   moderately Homo sapiens
    Urinarykidney   lowly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • high-mobility group (HMG1, HMG2 domains) box dna-binding domain
  • HOMOLOGY
    interspecies ortholog to Ssrp1, Mus musculus
    ortholog to Ssrp1, Rattus norvegicus
    ortholog to SSRP1, Pan troglodytes
    Homologene
    FAMILY
  • SSRP1 family
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    text a fraction of SSRP1 resides in the nucleoli with a distribution similar to that of Pol I subunit CAST/hPAF49 (Birch 2009)
    basic FUNCTION
  • facilitates transcript elongation through nucleosomes
  • essential for transcription by releasing RNA polymerase II from a nucleosome induced block and facilitating chromatin remodeling to productive transcription
  • a coregulator of SRF-dependent transcription in mammalian cells
  • binding specifically to DNA modified by the anticancer agent cisplatin
  • functioning as a co-activator of the transcriptional activator Tp63
  • having Spt16-dependent and -independent roles in regulating gene transcription
  • playing an important role for Pol I transcription elongation through chromatin and also associates with RNA Pol III complexes, is present at the chromatin of genes transcribed by Pol III and facilitates their transcription in cells (Birch 2009)
  • histone chaperone that could be universally involved in chromatin dynamics and transcription by all three nuclear RNA Pols in mammalian cells (Birch 2009)
  • has rapid chromatin-binding activity, the binding pattern of SSRP1 on chromatin changes after origin licensing, which may contribute to the establishment of its functional link to the DNA replication machinery
  • histone chaperone critical for nucleosome reorganization during replication, transcription, and DNA repair
  • promotes and subsequently restricts access to DNA as a result of dynamic nucleosome reorganization
  • is involved in the early steps of gene activation through its histone chaperone activities that serve to open the chromatin structure and facilitate transcription
  • facilitates transcription through chromatin and promotes nucleosome recovery
  • primary role of SSRP1 in RNF20 recruitment and the resulting chromatin remodeling for initiation of homologous recombination repair (HRR)
  • therefore plays central roles in building, maintaining, adjusting. and overcoming the chromatin barrier
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, elongation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of the chromatin specific elongation factor FACT with SUPT16H, indicating that it may promote nucleosome disruption upon transcription (see FACTP140) and forming a complex with the heterotetramer CSNK2A1/CSNK2A2
  • part of chromatin remodeling complex with two subunits: SSRP1 and SUPT16H
  • HSF1-RPA1 complex leads to preloading of RNA polymerase II and opens the chromatin structure by recruiting a histone chaperone SSRP1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • chromodomain helicase DNA binding protein 1, CHD1
  • serum response factor, SRF (
  • casein kinase 2, CK2
  • NIMA (never in mitosis gene a)- related kinase 9, NEK9 (14660563)
  • topoisomerase IIalpha
  • MCM helicase (16902406)
  • RNA Pol I and RNA Pol III complexes
  • SETD2 activity modulates SSRP1 recruitment and nucleosome dynamics, thereby repressing cryptic transcription initiation
  • SSRP1 complex promotes MYOG-dependent transcription and suggest that SSRP1 plays an important role in the establishment of the appropriate transcription profile in a differentiated muscle cell
  • interacts with DNA-binding surfaces of H2A/H2B dimers, facilitating uncoiling of DNA from the histone octamer
  • cell & other
    REGULATION
    inhibited by by CK2
    Other cleaved during apoptosis by caspase 3 and/or 7 ( SSRP1 degradation during apoptosis is a two-step process coupling caspase cleavage and ubiquitin-dependent proteolysis)(Landais 2006)
    phosphorylated by CK2
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS