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FLASH GENE
Symbol SSR2 contributors: - updated : 18-01-2006
HGNC name signal sequence receptor, beta (translocon-associated protein beta)
HGNC id 11324
Location 1q21-q23      Physical location : 155.978.839 - 155.990.758
Synonym symbol(s) TRAPB, HSD25, TLAP
DNA
TYPE functioning gene
STRUCTURE 11.00 kb     6 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
HCN3 1q22 hyperpolarization activated cyclic nucleotide-gated potassium channel 3 PKLR 1q21 pyruvate kinase, liver and RBC FDPS 1q21.2 farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) FLJ35976 1q22 hypothetical protein FLJ35976 RUSC1 1q21-q22 RUN and SH3 domain containing 1 ASH1L 1q21 ash1 (absent, small, or homeotic)-like (Drosophila) LOC284620 1q22 similar to CLDN6 MRPS29P1 1q21.3 mitochondrial ribosomal protein S29 pseudogene 1 FLJ10504 1q22 misato YAP 1q21.3 misato DAP3 1q21 death associated protein 3 LOC388705 1 similar to misato FLJ20203 1q22 hypothetical protein FLJ20203 SYT11 1q21.2 synaptotagmin XI RIT1 1q21.2 Ras-like without CAAX 1 KIAA0907 1q21 Ras-like without CAAX 1 GPR100 1q22 G protein-coupled receptor 100 ARHGEF2 1q11-q21 rho/rac guanine nucleotide exchange factor (GEF) 2 SSR2 1q21-q23 signal sequence receptor, beta (translocon-associated protein beta) C1orf6 1q21 chromosome 1 open reading Frame 6 MAPBPIP 1q22 mitogen-activated protein-binding protein-interacting protein RAB25 1q21.2 RAB25, member RAS oncogene family LOC92312 1q22-q23.1 hypothetical protein LOC92312 LMNA 1q21.2-q21.3 lamin A/C FLJ12287 1q22 hypothetical protein FLJ12287 similar to semaphorins LOC388706 1 LOC388706 KIAA0446 1q23.1 KIAA0446 gene product PMF1 1q12-q21.1 polyamine-modulated factor 1 BGLAP 1q25-q31 bone gamma-carboxyglutamate (gla) protein (osteocalcin) PAQR6 1q23.1 progestin and adipoQ receptor family member VI EST1B 1q21.2 Est1p-like protein B MGC13102 1q23.1 hypothetical protein MGC13102 MGC31963 1q23.1 kidney predominant protein NCU-G1 LOC391104 1 similar to Von Hippel-Lindau disease tumor suppressor (pVHL) (G7 protein) CCT3 1q23 chaperonin containing TCP1, subunit 3 (gamma) SSTK-IP 1q23.1 SSTK-interacting protein RHBG 1q21.3 Rhesus blood group, B glycoprotein CROC4 1q12-q25 Rhesus blood group, B glycoprotein MEF2D 1q12-q23 MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D) IQGAP3 1q21.3 IQ motif containing GTPase activating protein 3
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   highly
Reproductivefemale systemovary  highly
 male systemprostate  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
glycosylated
mono polymer heteromer , tetramer
HOMOLOGY
Homologene
FAMILY TRAP-beta family
CATEGORY receptor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,matrix
intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
basic FUNCTION
  • signal sequence receptor, beta, involved in protein translocation process
  • part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • glycosylated membrane protein constituent of endoplasmic reticulum
  • heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS