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FLASH GENE
Symbol SSH1 contributors: mct - updated : 18-05-2016
HGNC name slingshot homolog 1 (Drosophila)
HGNC id 30579
Location 12q24.11      Physical location : 109.176.466 - 109.251.359
Synonym name slingshot 1
Synonym symbol(s) SSH-1, KIAA1298, SSH1L, FLJ38102, FLJ21928, SSH1L
EC.number 3.1.3.16, 3.1.3.48
DNA
TYPE functioning gene
STRUCTURE 70.30 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 8537 115.3 1049 - Niwa 2002
  • stimulating cofilin-mediated actin turnover in lamellipodia
  • locally activated by translocation to and association with F-actin in lamellipodia in response to neuregulin-1beta and inhibited by 14-3-3 proteins sequestering it in the cytoplasm
  • - - 2367 77.3 692 - Niwa 2002
    - - 1031 - 148 - Niwa 2002
    - - 2459 78.8 703 - Niwa 2002
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbraincerebellum highly
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal A, B, and phosphatase domains of SSH1 were bound to IRS4 independently
  • a phosphatase domain distantly related to those of the family of mitogen-activated protein kinase phosphatases
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Ssh1 (84.6pc)
    homolog to rattus Ssh1 (83.2pc)
    Homologene
    FAMILY
  • SSH family
  • protein-tyrosine phosphatase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytoskeleton
    text lamellipodium
    basic FUNCTION
  • playing a role in actin dynamics by reactivating ADF/cofilin proteins
  • dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly
  • is a protein phosphatase that plays a crucial role in regulating actin dynamics by dephosphorylating and reactivating cofilin
  • association of IRS4 with SSH1 contributes likely to localized activation of cofilin in membrane protrusions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    SSH1 is a specific and essential component of the NOD1 pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CAMK2D and PPP3CA provide likely a switch-like mechanism that controls Ca-dependent LIMK1, SSH1 and CFL1 activation, and subsequently actin cytoskeletal reorganization
  • LIMK1 or SSH1 depletion inhibited RELA phosphorylation at Ser(536), a critical event conferring transcriptional competency to the bound NFKB
  • IRS4 is a novel SSH1-binding protein
  • IRS4 likely promotes cofilin dephosphorylation through sequential activation of PI3K and SSH1 but not through AKT1
  • cell & other
    REGULATION
    activated by F-actin (Yamamoto 2006)
    Other phosphorylated by PKD1 in response to RhoA activation and blocked in the cytoplasm, consequently blocking the formation of free actin-filament barbed ends (Eiseler 2009)
    activity of SSH1 is mainly regulated by its binding to filamentous actin (F-actin), which has been shown to strongly enhance its activity
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS