Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

SSFA2

contributors: mct - updated : 04-02-2015

HGNC name	sperm specific antigen 2
HGNC id	11319

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2q32.1      Physical location : 182.756.471 - 182.795.462
Synonym name	Ki- ras-induced actin-interacting protein
	cleavage signal-1 protein CS-1
Synonym symbol(s)	CS1, SPAG13, KIAA1927, KRAP

DNA

TYPE	anonymous DNA segment
STRUCTURE	39.02 kb     17 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001287505 - - 2661 NP_001274434 - 85 - 2007 17934691 NM_001130445 18 - 5338 NP_001123917 - 1259 - 2007 17934691 NM_006751 17 - 5220 NP_006742 - 1256 - 2007 17934691 NM_001287503 17 - 5272 NP_001274432 - 1237 - 2007 17934691 NM_001287504 16 - 5222 NP_001274433 - 1084 - 2007 17934691

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive stomach         Homo sapiens Endocrine pancreas       highly Hearing/Equilibrium ear       highly Reproductive female system uterus       Respiratory respiratory tract larynx     highly Urinary kidney tubule convoluted tubule proximal tubule   Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly Epithelial secretory glandular exocrine   Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Digestive chief Homo sapiens

cell lineage
cell lines
fluid/secretion	sperm

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	transmembrane regions
	a coiled-coil motif within its C terminus

HOMOLOGY

interspecies	homolog to murine Ssfa2
	homolog to chimpanzee LOC4597951

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytoskeleton
	intracellular,nucleus,nucleoplasm

basic FUNCTION	involved in some step of early cleavage of the fertilized oocyte
	might be involved in the regulation of filamentous actin and signals from the outside of the cells
	might be a cytoskeleton-associated protein involving the structural integrity and/or signal transductions in cancers
	might be involved in the regulation of F-actin
	may influence the cellular events related to attachment, migration, proliferation, and apoptosis
	may be a cytoskeleton-associated protein involving the structural integrity and/or signal transductions in cancers
	involved in the regulation of whole-body energy homeostasis and pancreatic exocrine system

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

constituent of cytoskeleton-associated proteins anchoring integral and/or signal proteins

INTERACTION

DNA

RNA

small molecule

protein

SSFA2 is associated with inositol 1,4,5-trisphosphate receptor (ITPR3) and is critical for the proper subcellular localization of ITPR3 in the liver and the pancreas

cell & other

REGULATION

activated by

activated Ki-ras

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in colon cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Krap-deficient mice show altered whole-body energy metabolism and resistance to diet-induced obesity and diabetes