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FLASH GENE
Symbol SSBP3 contributors: mct/np - updated : 27-04-2017
HGNC name single stranded DNA binding protein 3
HGNC id 15674
Location 1p32.3      Physical location : 54.692.195 - 54.872.092
Synonym name sequence-specific single-stranded-DNA-binding protein 1
Synonym symbol(s) SSDP, SSDP1, CSDP, FLJ10355
DNA
TYPE functioning gene
STRUCTURE 188.05 kb     18 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
KIAA0191 1p31-32 similar to Aspartate aminotransferase, mitochondrial precursor (Transaminase A) (Glutamate oxaloacetate transaminase-2) GPX6 6p21.33 glutathione peroxidase 6 (olfactory) MGC52498 1p32.3 hypothetical protein MGC52498 FLJ12439 1p32.3 hypothetical protein FLJ12439 FLJ13456 1p32.3 hypothetical protein FLJ13456 FLJ10948 1p32.3 hypothetical protein FLJ10948 SCP2 1p32 sterol carrier protein 2 PODN 1p32.3 podocan SLC1A7 1p33 solute carrier family 1 (glutamate transporter), member 7 CPT2 1p32 carnitine palmitoyltransferase II FLJ20580 1p32.3 hypothetical protein FLJ20580 MAGOH 1p34-p33 mago-nashi homolog, proliferation-associated (Drosophila) LRP8 1p34 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor FLJ40434 1p32.3 hypothetical protein FLJ40434 DMRTB1 1p33 DMRT-like family B with proline-rich C-terminal, 1 FLJ36155 1p32.3 likely ortholog of mouse Gli-similar 1 Kruppel-like zinc finger (Glis1) FLJ10407 1p32.3 hypothetical protein FLJ10407 DJ167A19.1 1p33-p32.1 hypothetical protein DJ167A19.1 DIO1 1p32-p33 deiodinase, iodothyronine, type I LOC51668 1p32.1-p33 HSPCO34 protein MGC8974 1p33-p32.1 hypothetical protein MGC8974 LOC388632 1 similar to heterogeneous nuclear ribonucleoprotein A3 LOC388633 1 similar to Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330) C1orf8 1p36-p31 chromosome 1 open reading frame 8 FLJ32112 1p32.3 hypothetical protein FLJ32112 LOC343190 LOC200008 1p32.3 hypothetical protein LOC200008 MRPL37 1p32.1 mitochondrial ribosomal protein L37 SSBP3 1p31.3 single stranded DNA binding protein 3 LOC391041 1 hypothetical gene supported by BC004945 THEA 1p31.3 thioesterase, adipose associated MGC27169  hyporthetical protein MGC27169 TTC4 1p31.3 tetratricopeptide repeat domain 4 DKFZp727A071 1p32.2 similar to tRNA synthetase class II FLJ20619 1p32.3 hypothetical protein FLJ20619 FLJ40201 1p32.3 hypothetical protein FLJ40201 DHCR24 1p32 24-dehydrocholesterol reductase LOC199964 1p32.3 hypothetical protein LOC199964 BSND 1p31 hypothetical protein LOC199964 PCSK9 1p32.3 proprotein convertase subtilisin/kexin type 9 USP24 1p32.2-p31.2 ubiquitin specific protease 24 LOC388634 1 similar to Ubiquitin carboxyl-terminal hydrolase 24 (Ubiquitin thiolesterase 24) (Ubiquitin-specific processing protease 24) (Deubiquitinating enzyme 24) LOC388635 1 LOC388635 LOC391042 1 similar to glycogenin LOC391043 1 similar to Aspartate aminotransferase, mitochondrial precursor (Transaminase A) (Glutamate oxaloacetate transaminase-2)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 - 3199 - 368 - 2015 26495868
18 - 3259 40.4 388 - 2015 26495868
17 - 3178 - 361 - 2015 26495868
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinelarge intestinecolon highly
Nervousnervecranial nerve  highly
Reproductivemale systemprostate  highly
Respiratoryrespiratory tractlarynx  highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a well-preserved FWD (FORWARD)-domain at the N-terminal end
  • a LISH domain
  • a proline-, glycine-, methionine- and serine-rich sequence in the central and C-terminal regions, possessing an entire transcription activity
  • HOMOLOGY
    interspecies homolog to murine Prp3
    ortholog to chicken Csdp
    Homologene
    FAMILY SSBP family
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • essential cofactor in the transcription regulation of embryonic development
  • acting in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex
  • BTBD9, CRLF3, and SSBP3 regulate likely neuronal morphology and the biogenesis/transport of synaptic vesicles
  • SSBP3 is a critical component of LDB1-ISL1 regulatory complexes, required for expression of critical beta-cell target genes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with LDB1 (cofactor of LDB1) to regulate development
  • SSBP3 inhibits LHX2 and LDB1 turnover, stimulates assembly of this DNA-binding complex, promotes its recruitment to the CGA promoter, and enhances CGA transcription
  • SSBP3 interacts with LDB1 and ISL1 in beta-cell lines and in human islets and is coexpressed with LDB1 and ISL1 pancreas tissue
  • SSBP2, SSBP3 control LMO4 and LDB1 protein abundance in a cancer context
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS