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FLASH GENE
Symbol SSBP1 contributors: mct - updated : 01-02-2016
HGNC name single-stranded DNA binding protein
HGNC id 11317
Location 7q34      Physical location : 141.438.175 - 141.450.257
Synonym name PWP1-interacting protein 17
Synonym symbol(s) SSBMT, SSBP, Mt-SSB, SOSS-B1, mtSSB
DNA
TYPE functioning gene
STRUCTURE 12.08 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site
text structure DNA binding site
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 628 - 148 - 2006 16860483
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas   highly
 parathyroid   highly
Skin/Tegumentskin   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a SSB domain
  • mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY single strand binding protein family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    text concentrated within perinuclear mitochondria that constitute active sites of mtDNA replication
    basic FUNCTION
  • binds and stabilizes DNA single strand for replication
  • with POLDIP2 is involved in the processes of mitochondrial fission and fusion, respectively
  • playing a role in cell survival
  • SSBP1 and SSBP2 form two separate complexes with similar structures, and both are required for efficient homologous recombination (HR)-dependent repair of DSBs and ATM-dependent signaling pathways
  • plays an important role in the DNA damage response and maintenance of genomic stability
  • plays important roles in DNA replication, recombination and repair through binding to single-stranded DNA
  • required for maintenance of mitochondrial DNA and 7S DNA but is not required for mitochondrial nucleoid organisation
  • may positively modulate CDKN1A to regulate cell cycle progression and DNA damage response
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cooperatively with TFAM, involved in stabilizing D-loops and in the maintenance of mtDNA
  • SSBP1 and SSBP2 form separate complexes with two identical proteins, INTS3 and C9ORF80
  • INTS3 is a novel partner of SSBP1 (forms a complex with SSBP1 by constitutively interacting with SSBP1 regardless of DNA damage)
  • directly binds CDKN1A and this interaction may prevent CDKN1A from ubiquitin-mediated degradation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    causes increased radiosensitivity, defective checkpoint activation and genomic instability
    constitutional     --low  
    co- deficient expression of POLG and SSBP1 genes could contribute to the development of mtDNA deletion
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    novel, promising therapeutic target for cancers such as hepatocellular carcinomas
    ANIMAL & CELL MODELS