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FLASH GENE
Symbol SRXN1 contributors: mct - updated : 17-08-2011
HGNC name sulfiredoxin 1 homolog (S. cerevisiae)
HGNC id 16132
Location 20p13      Physical location : 627.269 - 633.890
Synonym name
  • chromosome 20 open reading frame 139
  • sulfiredoxin-1 homolog
  • Synonym symbol(s) dJ850E9.2, C20orf139, Npn3, SRX1, YKL086W
    EC.number 1.8.98.2
    DNA
    TYPE functioning gene
    STRUCTURE 6.63 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2580 14 137 - 2004 15448164
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY sulfiredoxin family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzes a novel enzymatic reaction, the reduction of protein cysteine sulfinic acid, Cys-SO(2)(-)
  • deglutathionylation function of sulfiredoxin suggesting a central role in redox control with potential implications in cell signaling
  • role in the feedback regulation of AP1 activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • functionally significant target of AP1 blockade that may have value in cancer prevention or treatment
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    targeting the SXN1-PRDX4 axis may provide unique effective strategies for cancer prevention and treatment
    ANIMAL & CELL MODELS