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FLASH GENE
Symbol SRSF7 contributors: mct/npt - updated : 17/11/2008
HGNC name serine/arginine-rich splicing factor 7, 35kDa
HGNC id 10789
Location 2p22.1      Physical location : 38.970.742 - 38.978.636
Synonym name
  • zinc finger CCHC-type and RNA binding motif 2
  • splicing factor 9G8
  • aging-associated protein 3
  • Synonym symbol(s) 9G8, AAG3, RBM37, ZCCHC20, ZCRB2, HSSG1, SFRS7
    DNA
    TYPE functioning gene
    STRUCTURE 7.90 kb     8 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2489 27.2 238 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
     salivary gland   highly
    Endocrineadrenal gland   moderately
    Lymphoid/Immunethymus   moderately
    Nervousbrain    
    Reproductivefemale systemuterus  moderately
    Respiratorylung    
    Urinarybladder   highly
     kidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text differentially, in fetal tissues
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal RRM (RNA recognition motif) domain
  • a CCHC-type zinc knuckle motif
  • a C terminal RS domain
  • HOMOLOGY
    interspecies homolog to murine Sfrs7 (98.3 pc)
    Homologene
    FAMILY
  • arginine/serine-rich 10 (SR family)
  • splicing factor SR family
  • CATEGORY regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • required for pre-mRNA splicing
  • mediating protein-protein interaction within the intron during spliceosome assembly
  • independently binding to exonic enhancer sequences and recruiting components to adjacent introns for splice-site recognition and alternative splicing
  • playing a key role in regulation of exon 10 splicing and imply a pathogenic role in neurodegenerative diseases
  • play a role in mRNA export, in particular of histone mRNAs (Hargous 2006)
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the E commitnent complex in the spliceosome assembly pattern
  • INTERACTION
    DNA
    RNA binding
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with CCNL2 and CPSF6
  • cell & other
    REGULATION
    Other extensively phosphorylated on serine residues in the RS domain
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS