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FLASH GENE
Symbol SRSF6 contributors: mct/npt - updated : 26-01-2013
HGNC name splicing factor, arginine/serine-rich 6
HGNC id 10788
Location 20q13.11      Physical location : 42.086.503 - 42.092.242
Synonym name
  • pre-mRNA splicing factor SRP55
  • splicing factor, arginine/serine-rich, 55 kDa
  • Synonym symbol(s) D1S2417, SRP55, B52, MGC5045, SFRS6
    DNA
    TYPE functioning gene
    STRUCTURE 5.74 kb     6 Exon(s)
    MAPPING cloned   linked N status provisional
    Map cen - D20S99 - D20S170 - TOP1 - PLCG1 - D20S818 - D20S108 - MYBL2 - SDC4 - SFRS6 - D20S96 - qter
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    text three transcripts differing by their C terminus
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3755 39 344 - 2010 20685659
  • srp55.1
  • lacking exon 3
  • - splicing 1700 - 135 - 2010 20685659
    lacking 7 exons the RS domain
    - splicing 1100 - 335 - 2010 20685659
    lacking exon 3
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   highly
    Reproductivemale systemprostate  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one N terminal RNP (RRM) motif
  • a region homolog to RRM
  • a C terminal RS domain (hyperphosphorylation at the RS domain appears to require the RNA-binding activity)
  • HOMOLOGY
    interspecies homolog to C.elegans W02B12.3
    Homologene
    FAMILY
  • arginine/serine-rich 10 (SR family)
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • mediating protein-protein interaction within the intron during spliceosome assembly
  • independently binding to exonic enhancer sequences and recruiting components to adjacent introns for splice-site recognition and alternative splicing
  • involved in mRNA splicing and may play a role in the determination of alternative splicing
  • can be hyperphosphorylated under different circumstances whereby its fate is differentially influenced
  • SRSF5 and SRSF6, promote human immunodeficiency virus type 1 (HIV-1) Gag translation from unspliced (intron-containing) viral RNA
  • SRSF6 and SRSF4 induce production of HIV-1 vpr mRNA by inhibiting the 5prime-splice site of exon 3
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    text mRNA
    PATHWAY
    metabolism
    signaling
    a component
  • in the E commitnent complex in the spilceosome assembly pattern
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DYRK1A interacted with SRSF6 and mainly phosphorylated its proline-rich domain
  • promoted MAPT exon 10 inclusion, and the promotion of MAPT exon 10 inclusion by SRSF6 required the arginine/serine-rich region, which was responsible for the subnucleic speckle localization
  • cell & other
    REGULATION
    activated by DNA damage in the absence of TP53, and depletion of its activity increased resistance to DNA damage in TP53-dependant manner
    repressed by PNN, that induces reduced expression of SRSF6
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS