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FLASH GENE
Symbol SRSF5 contributors: mct - updated : 20-02-2015
HGNC name splicing factor, arginine/serine-rich 5
HGNC id 10787
Location 14q24.2      Physical location : 70.233.828 - 70.238.721
Synonym name
  • pre-mRNA-splicing factor SRP40
  • delayed-early protein HRS
  • Synonym symbol(s) SRP40, HRS, SFRS5
    DNA
    TYPE functioning gene
    STRUCTURE 4.89 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1800 - 107 ubiquitous, prominent in retina Screaton
    8 - 1517 31 272 ubiquitous, prominent in retina Screaton, Olsen (2006)
    - - 1010 - 107 - Screaton
    - - 600 - - - Screaton
    6 exons
    - - 1650 - 272 - Olsen (2006)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Lymphoid/Immunespleen   highly
     thymus   highly
    Reproductivefemale systemuterus  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • alternative pre m-RNA splicing factor containing one N terminal RNP (RRM) motif
  • a region of homology to RRH
  • a C terminal RS domain
  • HOMOLOGY
    Homologene
    FAMILY
  • splicing factor SR family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • mediating protein-protein interaction within the intron during spliceosome assembly
  • independently binding to exonic enhancer sequences and recruiting components to adjacent introns for splice-site recognition and alternative splicing
  • regulates the splicing of CREM via its interactions with multiple ESE (exon splicing enhancers) motifs present in the alternatively exons of CREM
  • SRSF5 and SRSF6, promote human immunodeficiency virus type 1 (HIV-1) Gag translation from unspliced (intron-containing) viral RNA
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    text mRNA
    PATHWAY
    metabolism
    signaling
    a component
  • the E commitment complex of the spliceosome assembly pattern
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    repressed by PNN, that induces reduced expression of SRSF5
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    SRSF5-CCAR1 axis may be valuable targets for cancer therapeutics
    ANIMAL & CELL MODELS