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FLASH GENE
Symbol SRSF4 contributors: mct - updated : 26-01-2013
HGNC name serine/arginine-rich splicing factor 4
HGNC id 10786
Location 1p35.3      Physical location : 29.474.250 - 29.508.637
Synonym name pre-mRNA-splicing factor SRP75
Synonym symbol(s) SRP75, SRP001LB, SFRS4
DNA
TYPE functioning gene
STRUCTURE 34.39 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
Map cen - D1S482 - CNR2 - FUCA1 - D1S2674 - TCEB3 - ID3 - RHD - CD52 - D1S2749 - D1S449 - SFRS4 - D1S2639 - D1S242 - cen
Authors Gene Map 98
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 2535 56.5 494 - 1999 10077565
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   moderately
Digestiveesophagus   highly
 intestine   moderately
 liver   moderately
Endocrineadrenal gland   highly
 thyroid   highly
Hearing/Equilibriumear   highly
Lymphoid/Immunespleen   moderately
 tonsils   moderately
Reproductivefemale systembreastmammary gland moderately
 female systemplacenta  moderately
Respiratoryrespiratory tractlarynx  moderately
Urinarykidney   moderately
cell lineage
cell lines
fluid/secretion moderately in blood, predominantly in lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal RNP (RRM) motif
  • a glycine-rich region
  • an internal region homolog to RRM (RNA recognition motif) domain
  • a C-terminal RS domain
  • HOMOLOGY
    Homologene
    FAMILY
  • arginine/serine-rich 10 splicing factor (SR) family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • playing a probable role in alternative splice site selection during pre-mRNA splicing
  • mediating protein-protein interaction within the intron during spliceosome assembly
  • independently binding to exonic enhancer sequences and recruiting components to adjacent introns for splice-site recognition and alternative splicing
  • SRSF6 and SRSF4 induce production of HIV-1 vpr mRNA by inhibiting the 5prime-splice site of exon 3
  • contribute to the execution of gene-expression programs through their association with distinct endogenous mRNAs
  • SRSF3 and SRSF4 are implicated in histone mRNA metabolism
  • SRSF3 and SRSF4 display unique RNA binding properties underlying diverse cellular regulatory mechanisms, with shared as well as unique coding and non-coding targets
  • CELLULAR PROCESS nucleotide, transcription, maturation
    nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    text mRNA
    PATHWAY
    metabolism
    signaling
    a component component of the E commitnent complex in the spliceosome assembly pattern
  • found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRP70, SNRPA1, SRRM1 and SRRM2
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • interacting with PNN
  • three SR-rich proteins were identified that interact with the C-terminus of PNN: SRSF4 and SRRM2, known components of spliceosome machinery, and PNISR
  • SRSF3 and SRSF4 associate with hundreds of distinct, functionally related groups of transcripts that change in response to neural differentiation
  • binds to the proximal downstream intron of MAPT exon 10 at the FTDP-17 hotspot region and interacts with RBMX and PCBP2 (increased exon 10 inclusion in FTDP mutants may arise from weakened SRSF4 binding)
  • cell & other
    REGULATION
    Other extensively phosphorylated on serine residues in the RS domain
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in newly diagnosed acute myeloid leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS