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FLASH GENE
Symbol SRSF3 contributors: mct/npt/pgu - updated : 05-03-2019
HGNC name serine/arginine-rich splicing factor 3
HGNC id 10785
Location 6p21.31      Physical location : 36.562.089 - 36.572.243
Synonym name
  • pre-mRNA-splicing factor SRP20
  • splicing factor, arginine/serine-rich, 20-kD
  • Synonym symbol(s) SRP20, SFRS3
    DNA
    TYPE functioning gene
    STRUCTURE 10.16 kb     6 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    text two in mouse
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3144 - 164 - 2006 17036044
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal RNP (RRM) motif
  • a zinc knuckle motif
  • a C terminal RS domain
  • HOMOLOGY
    interspecies ortholog to murine Sfrs3
    Homologene
    FAMILY
  • splicing factor SR family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • mediating protein-protein interaction within the intron during spliceosome assembly
  • independently binding to exonic enhancer sequences and recruiting components to adjacent introns for splice-site recognition and alternative splicing
  • play a role in mRNA export, in particular of histone mRNAs
  • with CUGBP1, SFRS1, act antagonistically to regulate insulin receptor alternative splicing and the relative ratios of SFRS1, SFRS3 to CUGBP1 in different cells determine the degree of exon inclusion
  • SR protein splicing factors, associated with interphase chromatin, and released from hyperphosphorylated mitotic chromosomes, but reassociate with chromatin late in M-phase
  • contribute to the execution of gene-expression programs through their association with distinct endogenous mRNAs
  • SRSF3 and SRSF4 are implicated in histone mRNA metabolism
  • SRSF3 and SRSF4 display unique RNA binding properties underlying diverse cellular regulatory mechanisms, with shared as well as unique coding and non-coding targets
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    text mRNA
    PATHWAY
    metabolism
    signaling
    a component
  • the E commitnent complex of the spliceosome pattern
  • INTERACTION
    DNA
    RNA
    small molecule other,
    protein
  • SRSF3 and SRSF4 associate with hundreds of distinct, functionally related groups of transcripts that change in response to neural differentiation
  • SRSF3 and HNRNPH1 are the first splicing factors identified which regulate the production of these functionally distinct ERBB2 splice variants and therefore maybe important for the regulation of ERBB2 signaling
  • cell & other
  • downstream effector of insulin
  • REGULATION
    activated by CHD1
    SFRS12
    colocalizing in paraspeckles, involved in transcriptional control and with the 68-kDA subunit (CPSF6) of cleavage factor Im, and involved in transcriptional control and RNA processing
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in newly diagnosed acute myeloid leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS