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FLASH GENE
Symbol SRSF2 contributors: mct/npt/pgu - updated : 19-10-2011
HGNC name serine/arginine-rich splicing factor 2
HGNC id 10783
Location 17q25.2      Physical location : 74.730.198 - 74.733.493
Synonym name
  • PR264, ribonucleoprotein 80
  • splicing factor 35
  • Synonym symbol(s) PR264, SC35, SC-35, SFRS2A, SRp30b, SFRS2
    DNA
    TYPE functioning gene
    STRUCTURE 3.22 kb     2 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2922 - 221 - 2008 18025108
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinesmall intestine  highly
    Lymphoid/Immunespleen   highly
    Nervousbrain     Mus musculus
    Urinarybladder   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Mus musculus
    Nervousoligodendrocyte Mus musculus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal RNP (RRM) motif
  • a C terminal RS domain, ribonucleoprotein 80
  • HOMOLOGY
    Homologene
    FAMILY
  • Ser-Rich Arg (SR) proteins family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • colocalized with SIR1 and RP9 in nuclear speckles
  • basic FUNCTION
  • alternative pre m-RNA splicing factor, mediating protein-protein interaction within the intron during spliceosome assembly
  • independently binding to exonic enhancer sequences and recruiting components to adjacent introns for splice-site recognition and alternative splicing
  • involved in the regulation of DNA stability and depletion of SRSF2 can lead to genomic instability
  • serine/arginine-rich protein belonging to the family of SR proteins that are crucial regulators of constitutive and alternative pre-mRNA splicing
  • did not affect tau transcription, but stabilized tau mRNA by binding to the SC35-like element of exon 10
  • new function of SRSF2 in the process of cellular senescence and CDKN1A is a key target of SRSF2 in this setting
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    text mRNA
    PATHWAY
    metabolism
    signaling
    a component
  • of the E commitnent in the spliceosome assembly pattern
  • can form a complex with splicing factor SFRS2 and plays an important role in constitutive pre-mRNA splicing, alternative splicing, and transcriptional activation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ELF5-binding proteins that could activate splicing of an enhancer-dependent splicing reporter through ELF5
  • CIR1 interact with U2AF1 through the BA domain, with SRSF2 and SF2/ASF through the RS domain, and with RP9 outside the BA domain
  • direct transcriptional target of E2F1
  • interacting with KAT5 (acetylates SRSF2 on its lysine 52 residue inside the RNA recognition motif, and promotes its proteasomal degradation)
  • ZRSR2 physically interacts with U2AF2, as well as SRSF1 and SRSF2, with a distinct function from its homologue, U2AF1
  • cell & other
    REGULATION
    activated by E2F12 (in response to DNA-damaging agents and is required for apoptosis in response to these drugs)
    repressed by PNN, that induces reduced expression of SRSF2
    Other lysine acetylation is a crucial post-translational modification regulating SRSF2 protein level and activity in response to genotoxic stress
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    lowering the level of secreted Abeta APP and may have a role in treating Alzheimer's disease
    tumoral germinal mutation      
    in myelodysplasia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS