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FLASH GENE
Symbol SRRT contributors: mct/npt/pgu - updated : 09-07-2012
HGNC name serrate RNA effector molecule homolog (Arabidopsis)
HGNC id 24101
Location 7q22.1      Physical location : 100.472.700 - 100.486.285
Synonym name
  • ARS2 protein
  • arsenite resistance protein
  • arsenite-resistance protein 2
  • arsenate resistance protein 2
  • arsenate resistance protein ARS2
  • serrate RNA effector molecule homolog
  • serrate
  • Synonym symbol(s) ASR2, MGC126427, ARS2
    DNA
    TYPE functioning gene
    STRUCTURE 13.58 kb     20 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map cen - D7S2498 - D7S2480 - SRRT - D7S477 - D7S662 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 splicing 3032 100 876 - 2009 19632182
    20 - 3029 - 875 - 2009 19632182
    20 - 3020 - 872 - 2009 19632182
    20 - 3017 - 871 - 2009 19632182
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly Homo sapiens
    Digestiveintestinelarge intestinecolon lowly Homo sapiens
     intestinesmall intestine  lowly Homo sapiens
     liver   lowly Homo sapiens
    Lymphoid/Immunespleen   lowly Homo sapiens
     thymus   lowly Homo sapiens
    Nervousbrain   moderately Homo sapiens
    Reproductivefemale systemplacenta  moderately Homo sapiens
    Respiratorylung   lowly
    Urinarykidney   moderately Homo sapiens
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal arginine-rich domain
  • a central RNA-binding domain
  • a zinc finger, that are common in RNA-binding proteins
  • HOMOLOGY
    interspecies ortholog to Srrt, Mus musculus
    ortholog to srrt, Danio rerio
    Homologene
    FAMILY
  • arsenite-resistance protein 2 (ARS2) family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • confering arsenite resistance
  • essential for early mammalian development and is likely involved in an essential cellular process
  • a role in RNA interference regulation during cell proliferation
  • necessary and sufficient to promote neural stem cell self-renewal, and that it does so by positively regulating the expression of Sox2
  • transcription factor that controls the multipotent progenitor state of neural stem cells through direct activation of the pluripotency factor Sox2
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text important for miRNA biogenesis and critical for cell proliferation
    PATHWAY
    metabolism
    signaling
    a component
  • component of the nuclear RNA cap-binding complex
  • component of the nuclear cap-binding complex that contributes to microRNA biogenesis and is required for cellular proliferation
  • INTERACTION
    DNA
  • a specific region within the 6-kilobase neural stem cell enhancer of Sox2
  • RNA
    small molecule
    protein
  • Cip1, Ephb4, Zan and Perq1
  • Nuclear Cap-Binding Complex
  • FLASH (CASP8AP2)
  • contributes to histone mRNA 3prime end formation and expression and these functional properties of SRRT are negatively regulated by interaction with RN7SK
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Ars2 nuclear localization is ablated in ARS2-null embryos, which in turn die around the time of implantation, ARS2-null blastocysts contained a significantly greater number of apoptotic cells than wild-type or heterozygous blastocysts
  • Deletion of Ars2 is developmentally lethal, and deletion in adult mice led to bone marrow failure whereas parenchymal organs composed of nonproliferating cells were unaffected
  • selective knockdown of Ars2 in cells expressing glial fibrillary acidic protein within the adult subventricular zone depletes the number of neural stem cells and their neurogenic capacity