Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

SRRM2

contributors: mct - updated : 27-02-2020

HGNC name	serine/arginine repetitive matrix 2
HGNC id	16639

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16p13.3      Physical location : 2.802.329 - 2.821.411
Synonym name	splicing coactivator subunit SRm300
	RNA binding protein
	300 kDa nuclear matrix antigen
	serine/arginine-rich splicing factor-related nuclear matrix protein
	of 300 kDa
Synonym symbol(s)	SRL300, SRM300, KIAA0324, CWF21, 300-KD, CWF21, FLJ21926, FLJ22250, MGC40295, DKFZp686O15166

DNA

TYPE	functioning gene
STRUCTURE	20.51 kb     15 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016333 15 - 9379 NP_057417 300 2752 - 1998 9531537 SRL300 a unique RNA binding region,two large RS domain and many phosphorylation sites SRM300 - - 7790 252 2296 - 2010 20161708 numerous SR dipeptides and two long polyserine domains shorter transcript of SRRM2 was 1.7 fold upregulated in the substantia nigra of Parkinson disease vs controls

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen           thymus         Cardiovascular heart         Digestive liver         Endocrine pancreas         Nervous brain           spinal cord       highly Reproductive male system prostate       Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal     Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a enhancer of microexons' (EMIC) domain, necessary and sufficient for microexon splicing, and functions by interacting with the earliest components required for exon recognition

HOMOLOGY

interspecies	homolog to Drosophila cg3961
	homolog to C.elegans y65b4bl.5
	ortholog to yeast Cwc21

Homologene

FAMILY	splicing factor SR family
	CWC21 family

CATEGORY

RNA associated , antigen

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles

basic FUNCTION	nuclear matrix antigen
	serine/arginine-repeat protein shown previously to associate with the splicing coactivator and 3prime-end processing stimulatory factor, SRRM1
	multiple functions for SRRM2 in the splicing process, including an important role in the activation of splicing in association with ISY1
	potential mechanism whereby SRm300/SRRM2, might influence splice site selection in human cells
	cellular complexes comprising CACTIN, DHX8 and SRRM2 sustain precise chromosome segregation, genome stability and cell proliferation by allowing faithful splicing of specific pre-mRNAs

CELLULAR PROCESS

nucleotide, RNA splicing

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	component of the SRm160/300 complex of nuclear matrix protein
	is part of the RNA splicing machinery

INTERACTION

DNA

RNA	pre-mRNA dependent on RNU1A and stabilized by RNU2

small molecule

protein	SRRM1
	SFRS5
	three SR-rich proteins were identified that interact with the C-terminus of PNN: SRSF4 and SRRM2, known components of spliceosome machinery, and PNISR
	CACTIN physically and functionally interacts with the spliceosome-associated factors DHX8 and SRRM2

cell & other

REGULATION

repressed by

PNN, that induces reduced expression of SRRM2

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene	strong candidate gene for Parkinson disease
Marker
Therapy target

ANIMAL & CELL MODELS