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FLASH GENE
Symbol SRRM2 contributors: mct - updated : 26-01-2013
HGNC name serine/arginine repetitive matrix 2
HGNC id 16639
Location 16p13.3      Physical location : 2.802.329 - 2.821.411
Synonym name
  • splicing coactivator subunit SRm300
  • RNA binding protein
  • 300 kDa nuclear matrix antigen
  • serine/arginine-rich splicing factor-related nuclear matrix protein
  • of 300 kDa
    Synonym symbol(s) SRL300, SRM300, KIAA0324, CWF21, 300-KD, CWF21, FLJ21926, FLJ22250, MGC40295, DKFZp686O15166
    DNA
    TYPE functioning gene
    STRUCTURE 19.08 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ39075 16p13.3 hypothetical protein FLJ39075 KCTD5 16p13.3 potassium channel tetramerisation domain containing 5 MPN 16p13.3 pancreasin SRRM2 16p13.3 serine/arginine repetitive matrix 2 TCEB2 13q12.1 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) LOC246718 16p12.3 ranscription elongation factor B (SIII), polypeptide 2 (18kD, elongin B) pseudogene EOS 16p13.3 serine protease EOS TESSP1  testis serine protease 1 PRSS21 16p13.3 protease, serine, 21 (testisin) LOC124220 16p13.3 similar to common salivary protein 1 MGC52282 16p13.3 hypothetical protein MGC52282 PRSS22 16p13.3 protease, serine, 22 LOC114984 16p13.3 hypothetical protein BC014089 DKFZp761A132 16p13.3 hypothetical protein DKFZp761A132 FLJ30002 16p13.3 hypothetical protein FLJ30002 KREMEN2 16p13.3 kringle containing transmembrane protein 2 PKMYT1 16p13.3 kringle containing transmembrane protein 2 LOC388205 16 similar to RIKEN cDNA 1520401A03 gene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 9379 300 2752 - 1998 9531537
  • SRL300
  • a unique RNA binding region,two large RS domain and many phosphorylation sites
  • - - 7790 252 2296 - 2010 20161708
  • numerous SR dipeptides and two long polyserine domains
  • shorter transcript of SRRM2 was 1.7 fold upregulated in the substantia nigra of Parkinson disease vs controls
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
     thymus    
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain    
     spinal cord   highly
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    Muscularstriatumskeletal  
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to Drosophila cg3961
    homolog to C.elegans y65b4bl.5
    ortholog to yeast Cwc21
    Homologene
    FAMILY
  • splicing factor SR family
  • CWC21 family
  • CATEGORY RNA associated , antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • nuclear matrix antigen
  • serine/arginine-repeat protein shown previously to associate with the splicing coactivator and 3prime-end processing stimulatory factor, SRRM1
  • multiple functions for SRRM2 in the splicing process, including an important role in the activation of splicing in association with ISY1
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the SRm160/300 complex of nuclear matrix protein
  • INTERACTION
    DNA
    RNA pre-mRNA dependent on RNU1A and stabilized by RNU2
    small molecule
    protein
  • SRRM1
  • SFRS5
  • three SR-rich proteins were identified that interact with the C-terminus of PNN: SRSF4 and SRRM2, known components of spliceosome machinery, and PNISR
  • cell & other
    REGULATION
    repressed by PNN, that induces reduced expression of SRRM2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene strong candidate gene for Parkinson disease
    Marker
    Therapy target
    ANIMAL & CELL MODELS