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FLASH GENE
Symbol SRPX contributors: mct - updated : 11-02-2012
HGNC name sushi-repeat-containing protein, X chromosome
HGNC id 11309
Corresponding disease
RP3 retinitis pigmentosa 3
Location Xp11.4      Physical location : 38.008.588 - 38.080.177
Synonym symbol(s) ETX1, SCRP1, DRS
DNA
TYPE functioning gene
STRUCTURE 71.59 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map pter - CYBB - DXS140 - DYNLT3 - DXS352 - SRPX - RPGR - OTC OTC - cen
Authors Meindl (95, 96)
Physical map
LOC340571 Xp21.1 similar to hSIAH1 LOC392441 X similar to melanoma antigen LOC139604 Xp21.1 similar to hypothetical protein MGC33889 MGC34831 Xp21.1 hypothetical protein MGC34831 FLJ36601 Xp21.1 hypothetical protein FLJ36601 LOC158730 Xp21.1 hypothetical LOC158730 PRRG1 Xp21.1 proline-rich Gla (G-carboxyglutamic acid) polypeptide 1 LOC389844 X similar to ferritin, heavy polypeptide-like 17 LOC139249 Xp21.1 similar to hypothetical protein FLJ35782 FLJ42925 Xp21.1 FLJ42925 protein XK Xp21.1 Kell blood group precursor (McLeod phenotype) CYBB Xp21.1 cytochrome b-245, beta polypeptide (chronic granulomatous disease) TCTE1L Xp21.1 t-complex-associated-testis-expressed 1-like SC4MOP Xp21.1 sterol-C4-methyl oxidase pseudogene HYPM Xp21.1 sterol-C4-methyl oxidase pseudogene LOC340549 Xp21.1 similar to RIKEN cDNA 1700113O17 SYTL5 Xp21.1 synaptotagmin-like 5 SRPX Xp21.1 sushi-repeat-containing protein, X chromosome LOC286441 Xp21.1 hypothetical LOC286441 RPGR Xp21.1 retinitis pigmentosa GTPase regulator OTC Xp21.1 ornithine carbamoyltransferase LOC392442 X similar to BAG-family molecular chaperone regulator-1 (BCL-2 binding athanogene-1) (BAG-1) (Glucocorticoid receptor-associated protein RAP46) LOC392443 X similar to ferritin light chain LOC392444 X similar to Nucleolar transcription factor 1 (Upstream binding factor 1) (UBF-1) TM4SF2 Xp11.4-q11 transmembrane 4 superfamily member 2 LOC389845 X LOC389845 STRAIT11499 Xp11.4 hypothetical protein STRAIT11499 LOC389846 X hypothetical gene supported by BC043536 GAPDP1 Xp11.4-p11.23 glyceraldehyde-3-phosphate dehydrogenase pseudogene 1 LOC392445 X similar to 40S ribosomal protein S11 BCOR Xp11.4 BCL6 co-repressor LOC158624 Xp11.4 similar to IMP dehydrogenase (EC 1.1.1.205) I - human ATP6AP2 Xq21 ATPase, H+ transporting, lysosomal accessory protein 2 LOC347411 Xp11.4 similar to ENSANGP00000015797 MGC39350 Xp11.4 hypothetical protein MGC39350 CRSP2 Xp11.2-p11.4 cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa
RNA
TRANSCRIPTS type messenger
text two alternate transcripts
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1860 - 444 - 2002 12152160
9 - 1743 - 405 - 2002 12152160
9 - 1798 - 379 - 2002 12152160
10 - 1920 - 464 - 2002 12152160
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Endocrinepancreas    
Respiratorylung    
Visualeyeretina   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Visualcone photoreceptor
Visualrod photoreceptor
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
putative membrane protein
HOMOLOGY
interspecies homolog to short consensus repeat domain of selectins and complement proteins
homolog to sushi structure
Homologene
FAMILY
CATEGORY tumor suppressor
SUBCELLULAR LOCALIZATION     plasma membrane
text
  • SRPX was co-localized with RAB24 on punctuated structures during autophagy
  • basic FUNCTION
  • may regulate trabecular meshwork protein interactions involved in cell adhesion
  • apoptosis-inducing tumor suppressor
  • involved in the host defense against viral infection
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • could associate with RAB24 and the association with RAB24 was enhanced during autophagy
  • PELO interacts with HAX1, EIF3G and SRPX proteins and that this interaction occurs at the cytoskeleton
  • suppresses viral replication via MTOR-dependent pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) RP3
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    is closely correlated with development of prostate carcinoma, suggesting a tumor-suppressor function of the drs gene in this cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS