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FLASH GENE
Symbol SRPX contributors: mct - updated : 11-02-2012
HGNC name sushi-repeat-containing protein, X chromosome
HGNC id 11309
Corresponding disease
RP3 retinitis pigmentosa 3
Location Xp11.4      Physical location : 38.008.588 - 38.080.177
Synonym symbol(s) ETX1, SCRP1, DRS
DNA
TYPE functioning gene
STRUCTURE 71.59 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map pter - CYBB - DXS140 - DYNLT3 - DXS352 - SRPX - RPGR - OTC OTC - cen
Authors Meindl (95, 96)
RNA
TRANSCRIPTS type messenger
text two alternate transcripts
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1860 - 444 - 2002 12152160
9 - 1743 - 405 - 2002 12152160
9 - 1798 - 379 - 2002 12152160
10 - 1920 - 464 - 2002 12152160
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Endocrinepancreas    
Respiratorylung    
Visualeyeretina   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Visualcone photoreceptor
Visualrod photoreceptor
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
putative membrane protein
HOMOLOGY
interspecies homolog to short consensus repeat domain of selectins and complement proteins
homolog to sushi structure
Homologene
FAMILY
CATEGORY tumor suppressor
SUBCELLULAR LOCALIZATION     plasma membrane
text
  • SRPX was co-localized with RAB24 on punctuated structures during autophagy
  • basic FUNCTION
  • may regulate trabecular meshwork protein interactions involved in cell adhesion
  • apoptosis-inducing tumor suppressor
  • involved in the host defense against viral infection
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • could associate with RAB24 and the association with RAB24 was enhanced during autophagy
  • PELO interacts with HAX1, EIF3G and SRPX proteins and that this interaction occurs at the cytoskeleton
  • suppresses viral replication via MTOR-dependent pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) RP3
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    is closely correlated with development of prostate carcinoma, suggesting a tumor-suppressor function of the drs gene in this cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS