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FLASH GENE
Symbol SRPK1 contributors: mct/npt/pgu - updated : 15-01-2010
HGNC name SFRS protein kinase 1
HGNC id 11305
Location 6p21.31      Physical location : 35.800.811 - 35.888.957
Synonym name
  • serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors
  • SR protein kinase 1
  • Synonym symbol(s) SFRSK1
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 88.14 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 4760 - 862 - 2009 19674106
  • also called SRPK1a
  • interacts with the nuclear matrix protein scaffold attachment factor B1 (SAFB1) via its unique N-terminal domain, which differentiates it from SRPK1
  • 16 - 4361 - 655 - 2001 11509566
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas   predominantly Homo sapiens
    Reproductivemale systemtestis  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • RS domain protein kinase
  • HOMOLOGY
    interspecies ortholog to murine Srpk1
    intraspecies homolog to SRPK2
    Homologene
    FAMILY
  • SRPK family of kinases
  • CMGC Ser/Thr protein kinase family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • key pre-mRNA splicing factor in the nuclear speckles
  • both SRPK1 and SRPK2 are primarily localized in the cytoplasm despite having putative nuclear localization signals
  • basic FUNCTION
  • highly specific for the serine/arginine repeats, modulating the affinity between RS domain containing proteins and regulating the cellular distribution of their substrates
  • cell cycle regulator
  • controling localization of splicing factors
  • playing a role in the condensation of sperm chromatin
  • may play an important role in linking signaling to RNA metabolism in higher eukaryotic cells
  • phosphorylate serine/arginine (SR) domain-containing proteins in nuclear speckles and mediate the pre-mRNA splicing
  • involved in the molecular chaperone system that has been implicated in numerous signal transduction pathways and provide mechanistic insights into complex regulation of SR protein phosphorylation and alternative splicing in response to developmental cues and cellular signaling
  • in addition to phosphorylating SR proteins and regulating pre-mRNA splicing, SRPK1 and SRPK2 also play an important role in cell proliferation and apoptosis
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SAFB (with SRPK1a)
  • directly binds to the cochaperones DNAJC8 and AHA1, which mediate dynamic interactions of the kinase with the major molecular chaperones Hsp70 and Hsp90 in mammalian cells
  • WT1 bound to the SRPK1 promoter, and repressed expression through a specific WT1 binding site
  • cell & other
    REGULATION
    Other regulated by SAFB proteins (regulators of SRPK1 and SRPK2 activity underlining the importance of the assembly of transient intranuclear complexes in cellular regulation)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS