Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

SRPK1

contributors: mct/npt/pgu - updated : 15-01-2010

HGNC name	SFRS protein kinase 1
HGNC id	11305

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6p21.31      Physical location : 35.800.811 - 35.888.957
Synonym name	serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors
	SR protein kinase 1
Synonym symbol(s)	SFRSK1
EC.number	2.7.11.1

DNA

TYPE	functioning gene
STRUCTURE	88.14 kb     16 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant a - splicing 4760 isoform a - 862 - 2009 19674106 also called SRPK1a interacts with the nuclear matrix protein scaffold attachment factor B1 (SAFB1) via its unique N-terminal domain, which differentiates it from SRPK1 NM_003137 16 - 4361 NP_003128 - 655 - 2001 11509566

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Endocrine pancreas       predominantly Homo sapiens Reproductive male system testis     highly Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

RS domain protein kinase

HOMOLOGY

interspecies

ortholog to murine Srpk1

intraspecies

homolog to SRPK2

Homologene

FAMILY	SRPK family of kinases
	CMGC Ser/Thr protein kinase family

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
text	key pre-mRNA splicing factor in the nuclear speckles
	both SRPK1 and SRPK2 are primarily localized in the cytoplasm despite having putative nuclear localization signals

basic FUNCTION	highly specific for the serine/arginine repeats, modulating the affinity between RS domain containing proteins and regulating the cellular distribution of their substrates
	cell cycle regulator
	controling localization of splicing factors
	playing a role in the condensation of sperm chromatin
	may play an important role in linking signaling to RNA metabolism in higher eukaryotic cells
	phosphorylate serine/arginine (SR) domain-containing proteins in nuclear speckles and mediate the pre-mRNA splicing
	involved in the molecular chaperone system that has been implicated in numerous signal transduction pathways and provide mechanistic insights into complex regulation of SR protein phosphorylation and alternative splicing in response to developmental cues and cellular signaling
	in addition to phosphorylating SR proteins and regulating pre-mRNA splicing, SRPK1 and SRPK2 also play an important role in cell proliferation and apoptosis

CELLULAR PROCESS	nucleotide, chromatin organization, remodeling
	nucleotide, RNA splicing

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	SAFB (with SRPK1a)
	directly binds to the cochaperones DNAJC8 and AHA1, which mediate dynamic interactions of the kinase with the major molecular chaperones Hsp70 and Hsp90 in mammalian cells
	WT1 bound to the SRPK1 promoter, and repressed expression through a specific WT1 binding site

cell & other

REGULATION

Other

regulated by SAFB proteins (regulators of SRPK1 and SRPK2 activity underlining the importance of the assembly of transient intranuclear complexes in cellular regulation)

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS