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FLASH GENE
Symbol SRP9 contributors: mct/npt - updated : 16-03-2010
HGNC name signal recognition particle 9kDa
HGNC id 11304
Location 1q42.12      Physical location : 225.965.514 - 225.978.165
Synonym symbol(s) ALURBP, MGC110981
DNA
TYPE functioning gene
STRUCTURE 12.65 kb     3 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1648 - 82 - -
3 - 1524 - 86 - -
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • S domain
  • conjugated RiboP
    HOMOLOGY
    Homologene
    FAMILY
  • Srp9 family of GTP binding proteins
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • targeting secretory proteins to the rough endoplasmic reticulum membrane
  • SRP9/14 subunit of the signal recognition particle binds to a variety of Alu-like RNAs (Bovia 1997)
  • recognizes signal sequences of nascent protein chains emerging from the ribosome (Halic 2004)
  • essential for targeting nascent chains to the endoplasmic reticulum, and it delays nascent chain elongation in cell-free translation systems (Lakkaraju 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming with SRP9 and SRPRNA the elongation arrest domain of SRP
  • subunit of the signal recognition particle (SRP) which is a ribonucleoprotein complex (SRP72, SRP68, SRP54,SRP19, SRP14 and SRP9)
  • INTERACTION
    DNA
    RNA required for SRP14 binding to the Alu homologous region of 7S RNA
    small molecule
    protein
  • SRPR
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS