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FLASH GENE
Symbol SRP72 contributors: mct - updated : 09-05-2012
HGNC name signal recognition particle 72kDa
HGNC id 11303
Corresponding disease
BMFS1 bone marrow failure syndrome 1
Location 4q12      Physical location : 57.333.761 - 57.369.846
DNA
TYPE functioning gene
STRUCTURE 36.09 kb     19 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
KDR 4q12 kinase insert domain receptor (a type III receptor tyrosine kinase) FLJ13352 4q12 hypothetical protein FLJ13352 TPARL 4q12 TPA regulated locus CLOCK 4q12 clock homolog (mouse) GCPHLP 4q12 likely ortholog of mouse germ cell-specific phosphoducin-like protein Mgcphlp NMU 4q12 neuromedin U SEC3 FLJ13621 4q12 hypothetical protein FLJ13621 KIAA0635 4q12-q13.3 hypothetical protein FLJ13621 KIAA1211 4q12 KIAA1211 protein MRPL22P1 4q12 KIAA1211 protein NRPS998 4q12 2-aminoadipic 6-semialdehyde dehydrogenase PPAT 4q12 phosphoribosyl pyrophosphate amidotransferase PAICS 4q12 phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase SRP72 1q32 signal recognition particle 72kDa LOC132946 4q12 similar to MGC69138 protein LOC391654 4 LOC391654 GLDCP 4q12 glycine dehydrogenase (decarboxylase) pseudogene HOP 4q11-q12 homeodomain-only protein LOC391655 4 similar to 60S ribosomal protein L17 (L23) LOC285453 4q12 similar to APACD protein SPINK2 4q12 serine protease inhibitor, Kazal type, 2 (acrosin-trypsin inhibitor) REST 4q12 RE1-silencing transcription factor MGC3232 POLR2B 4q12 polymerase (RNA) II (DNA directed) polypeptide B, 140kDa IGFBP7 4q12 insulin-like growth factor binding protein 7 LOC255130 4q12 hypothetical LOC255130
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 3893 72 671 - 2006 16672232
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Endocrineparathyroid   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nine tetratricopeptide-like repeats (TPRs) poised to interact with other SRP or ribosomal proteins were predicted in the N-terminal region
  • a minimal region capable of forming a stable complex with an SRP RNA fragment encompassed AAs 545 to 585 of the full-length SRP72 and contained a lysine-rich cluster (KKKKKKKKGK) at postions 552 to 561 as well as a conserved Pfam motif
  • a C terminal domain of interaction with SRP68
  • HOMOLOGY
    interspecies homolog to C.elegans F08D12.1
    ortholog to murine Srp72
    homolog to rattus Rn.36055
    homolog to Xenopus Xl.5137
    homolog to zebrafish Dr.9066
    Homologene
    FAMILY
  • SRP72 family
  • CATEGORY antigen , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • playing a crucial role in targeting secretory proteins to rough endoplasmic reticulum membrane
  • participating in the elongation arrest function
  • implicated in binding to the SRP receptor and promoting the directional translocation of newly translated proteins bearing a signal sequence into the lumen of the ER
  • has at least two functions that are individually redundant and the conformation of the complex is critical for efficient completion of its biogenesis
  • component of the signal recognition particle (SRP), which is responsible for arresting translation of nascent proteins that are destined for the cell membrane or extracellular secretion and transferring them to the endoplasmic reticulum (ER) for correct trafficking
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • S domain made of a unique SRP RNA sequence and SRP9, SRP14, SRP19, SRP54, SRP68, SRP72
  • component of a ribonucleoprotein complex
  • SRP68 and SRP72 form a heterodimer
  • INTERACTION
    DNA
    RNA binding to 7S RNA in presence of SRP68
    small molecule
    protein
  • binding to SRPR
  • SRP68-SRP72 interaction remained stable at elevated salt concentrations and engaged approximately 150 amino acids from the N-terminal region of SRP72
  • cell & other
  • binding directly to the docking protein in the endoplasmic reticulum membrane
  • REGULATION
    repressed by inhibitors of the MAPK pathway that down-regulate the expression of SRP72 autoantigen in Jurkat cells
    Other cleaved during apoptosis
    ASSOCIATED DISORDERS
    corresponding disease(s) BMFS1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS