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FLASH GENE
Symbol SRP19 contributors: np - updated : 21-03-2003
HGNC name signal recognition particle 19kDa
HGNC id 11300
Location 5q21      Physical location : 112.196.992 - 112.203.603
DNA
TYPE functioning gene
STRUCTURE 6.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 894 16 144 - -
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivemale systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • very basic C-terminal domain of seven lysine residues interrupted by two glycine residues
  • conjugated RiboP
    mono polymer heteromer , monomer , dimer
    HOMOLOGY
    interspecies homolog to C.elegans Y46G5A.19 and F09F7.2
    Homologene
    FAMILY SRP19 family
    CATEGORY RNA associated , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • mediating the targeting of secretory and membrane proteins to the rough endoplasmic reticulum membrane
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of the signal recognition particle (SRP) which is a ribonucleoprotein complex consisting of a7S molecule of 300 nucleotides and six proteins subunits (SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9)
  • INTERACTION
    DNA
    RNA binding to 7S RNA
    small molecule
    protein
  • binding to the 54 kDa subunit of the SRP,required for binding SRP54 to the S domain of 7S RNA
  • binding to SRPR
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS