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FLASH GENE

Symbol

SRP19

contributors: np - updated : 21-03-2003

HGNC name	signal recognition particle 19kDa
HGNC id	11300

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5q21      Physical location : 112.196.992 - 112.203.603

DNA

TYPE	functioning gene
STRUCTURE	6.00 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed SRP19 - variant 1 - - 894 16 144 - -

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Reproductive male system testis

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		basic
STRUCTURE

motifs/domains

very basic C-terminal domain of seven lysine residues interrupted by two glycine residues

conjugated

RiboP

mono polymer

heteromer , monomer , dimer

HOMOLOGY

interspecies

homolog to C.elegans Y46G5A.19 and F09F7.2

Homologene

FAMILY

SRP19 family

CATEGORY

RNA associated , signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

mediating the targeting of secretory and membrane proteins to the rough endoplasmic reticulum membrane

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

subunit of the signal recognition particle (SRP) which is a ribonucleoprotein complex consisting of a7S molecule of 300 nucleotides and six proteins subunits (SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9)

INTERACTION

DNA

RNA	binding to 7S RNA

small molecule

protein	binding to the 54 kDa subunit of the SRP,required for binding SRP54 to the S domain of 7S RNA
	binding to SRPR

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS