basic FUNCTION
| involved in axon guidance and neurite outgrowth and in mental development |
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SRGAP, SRGAP2, SRGAP3 are not only involved in the regulation of the Slit-Robo signal transduction, but also in neuronal development and that the translocation of srGAPs is important for their functions |
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implicated in repulsive axon guidance and neuronal migration through Slit-Robo-mediated signal transduction |
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inhibitory role of SRGAP3 on actin dynamics, specifically on lamellipodia formation |
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controls actin and microtubule dynamics through negative regulation of RAC1 |
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has tumor suppressor-like activity in mammary epithelial cells, likely through its activity as a negative regulator of RAC1 |
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SRGAP3-mediated cytoskeletal reorganisation has an important influence on a variety of neurodevelopmental processes, which may be required for normal cognitive function |
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important modulator of actin cytoskeletal dynamics and has an important influence on a variety of neurodevelopmental processe |
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implicated in different critical aspects of neuronal development |
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via its interactions SRGAP3 could link receptor signalling events to the endocytic machinery |