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FLASH GENE
Symbol SRGAP2C contributors: mct - updated : 22-02-2016
HGNC name SLIT-ROBO Rho GTPase activating protein 2C
HGNC id 30584
Location 1p12      Physical location : -
Synonym symbol(s) BC112927, SRGAP2P1
DNA
TYPE functioning gene
SPECIAL FEATURE
text human-specific duplication of SRGAP2 in SRGAP2A, SRGAP2B, SRGAP2C
STRUCTURE 207.86 kb     10 Exon(s)
MAPPING cloned   linked   status
RNA
TRANSCRIPTS type
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 3347 - 458 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain     Homo sapiensAdult
 brain     Homo sapiensFetal
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiensAdult
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a truncated F-BAR domain that lacks the last C-terminal 49 AA
  • mono polymer dimer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • inhibition of SRGAP2 function by SRGAP2B, SRGAP2C has contributed to the evolution of the human neocortex and plays an important role during human brain development
  • SRGAP2C-induced neoteny extends the period of spine production with long-term consequences on their morphology
  • is the most likely duplicate to encode a functional protein and is among the most fixed human-specific duplicate genes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • SRGAP2C protein can dimerize with both SRGAP2A and SRGAP2C
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • both SRGAP2C, SRGAP2B can interact with ancestral SRGAP2A and inhibit its function
  • function of ancestral SRGAP2 is conserved between mouse and human and is inhibited by SRGAP2C expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS