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Symbol SRGAP2B contributors: mct - updated : 22-02-2016
HGNC name SLIT-ROBO Rho GTPase activating protein 2B
HGNC id 35237
Location 1q21.1      Physical location : -
Synonym symbol(s) SRGAP2L, SRGAP2P2
DNA
TYPE functioning gene
STRUCTURE 208.14 kb     9 Exon(s)
text structure human-specific duplication of SRGAP2 in SRGAP2A, SRGAP2B, SRGAP2C
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1835 - 458 - 2012 22559944
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain     Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a truncated F-BAR domain that lacks the last C-terminal 49 AA
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • inhibition of SRGAP2 function by SRGAP2B, SRGAP2C has contributed to the evolution of the human neocortex and plays an important role during human brain development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • both SRGAP2C, SRGAP2B can interact with ancestral SRGAP2A and inhibit its function
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS