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FLASH GENE

Symbol

SRGAP2

contributors: mct - updated : 22-02-2016

HGNC name	SLIT-ROBO Rho GTPase-activating protein 2
HGNC id	19751

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q32.1      Physical location : 206.516.199 - 206.637.782
Synonym name	SH3-type formin binding protein 2
Synonym symbol(s)	KIAA0456, FNBP2, srGAP3, ARHGAP34, FNBP2A

DNA

TYPE	functioning gene
STRUCTURE	260.98 kb     20 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

text structure

human-specific duplication of SRGAP2 in SRGAP2A, SRGAP2B, SRGAP2C

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_015326 22 - 6801 NP_056141 - 1071 - 2012 22559944 NM_001170637 22 - 6798 NP_001164108 - 1070 - 2012 22559944 NM_001300952 20 - 4932 NP_001287881 - 789 - 2012 22559944

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly Homo sapiens Fetal Reproductive female system ovary     lowly Urinary kidney       lowly

cell lineage
cell lines	in melanoma, germ cell tumors, chondrosarcoma and retinoblastoma
fluid/secretion

at STAGE

physiological period

pregnancy

Text	lowly in placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N-terminal F-BAR (Bin, Amphiphysin, Rvs) domain involved in membrane deformation, and FCH domain; F-BAR displays faster molecular dynamics than F-BAR(SRGAP3) and F-BAR(SRGAP1) at the plasma membrane, which correlates well with its increased potency to induce filopodia
	a FBH and a HR1 doamains
	a central Rho-GAP domain which specifically stimulates the GTPase activity of RAC1
	a C-terminal tail containing a SH3 domain

HOMOLOGY

intraspecies	homolog to RHO-GAP hematopoietic protein C1(ARHGAP4)
	paralog to SRGAP2B, SRGAP2C

Homologene

FAMILY	Rho GTPase family
	FNBP2 family protein

CATEGORY

regulatory , signaling

SUBCELLULAR LOCALIZATION	plasma membrane,junction
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus
text	is associated with synaptic membranes and is detected in the postsynaptic density

basic FUNCTION	axon guidance and neurite outgrowth
	couplingmembrane deformation to actin cytoskeleton reorganization in various cellular processes
	controls cortical neuron migration
	SRGAP, SRGAP2, SRGAP3 are not only involved in the regulation of the Slit-Robo signal transduction, but also in neuronal development and that the translocation of srGAPs is important for their functions
	negatively regulates neuronal migration and induces neurite outgrowth and branching through the ability of its F-BAR domain to induce filopodia-like membrane protrusions resembling those induced by I-BAR domains
	regulates neuronal morphogenesis through the ability of its F-BAR domain to regulate membrane deformation and induce filopodia formation
	implicated in neocortical development
	is enriched at excitatory synapses
	promotes spine maturation and limits spine density andco-regulates spine density with the length of spine neck
	regulates neurite outgrowth and neuronal migration by causing membrane protrusions reminiscent of the activity of I-BAR domain proteins
	SRGAP2 signaling network as a key regulator of contact inhibition of locomotion (CIL) in fibroblasts
	specifically controls the duration of RAC1 activity in contact protrusions, but not in contact-free protrusions

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with the intracellular domain of ROBO1
	physically interacts with protein arginine methyltransferase 5 (PRMT5)
	after RAC1-dependent activation of FMNL1, SRGAP2 mediates a potent mechanism to limit the duration of RAC1 action and inhibit formin activity during rapid actin dynamics
	inhibition of SRGAP2 function by SRGAP2B, SRGAP2C has contributed to the evolution of the human neocortex and plays an important role during human brain development
	function of ancestral SRGAP2 is conserved between mouse and human and is inhibited by SRGAP2C expression
	interplay between SRGAP1, SRGAP2 and SRGAP3 regulates neuronal differentiation and neurite outgrowth

cell & other

REGULATION

activated by

enhanced by SLIT*

inhibited by

inactivated by CDC42

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS