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FLASH GENE
Symbol SRGAP2 contributors: mct - updated : 22-02-2016
HGNC name SLIT-ROBO Rho GTPase-activating protein 2
HGNC id 19751
Location 1q32.1      Physical location : 206.516.199 - 206.637.782
Synonym name SH3-type formin binding protein 2
Synonym symbol(s) KIAA0456, FNBP2, srGAP3, ARHGAP34, FNBP2A
DNA
TYPE functioning gene
STRUCTURE 260.98 kb     20 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
text structure human-specific duplication of SRGAP2 in SRGAP2A, SRGAP2B, SRGAP2C
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 - 6801 - 1071 - 2012 22559944
22 - 6798 - 1070 - 2012 22559944
20 - 4932 - 789 - 2012 22559944
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly Homo sapiensFetal
Reproductivefemale systemovary  lowly
Urinarykidney   lowly
cell lineage
cell lines in melanoma, germ cell tumors, chondrosarcoma and retinoblastoma
fluid/secretion
at STAGE
physiological period pregnancy
Text lowly in placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N-terminal F-BAR (Bin, Amphiphysin, Rvs) domain involved in membrane deformation, and FCH domain; F-BAR displays faster molecular dynamics than F-BAR(SRGAP3) and F-BAR(SRGAP1) at the plasma membrane, which correlates well with its increased potency to induce filopodia
  • a FBH and a HR1 doamains
  • a central Rho-GAP domain which specifically stimulates the GTPase activity of RAC1
  • a C-terminal tail containing a SH3 domain
  • HOMOLOGY
    intraspecies homolog to RHO-GAP hematopoietic protein C1(ARHGAP4)
    paralog to SRGAP2B, SRGAP2C
    Homologene
    FAMILY
  • Rho GTPase family
  • FNBP2 family protein
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text is associated with synaptic membranes and is detected in the postsynaptic density
    basic FUNCTION
  • axon guidance and neurite outgrowth
  • couplingmembrane deformation to actin cytoskeleton reorganization in various cellular processes
  • controls cortical neuron migration
  • SRGAP, SRGAP2, SRGAP3 are not only involved in the regulation of the Slit-Robo signal transduction, but also in neuronal development and that the translocation of srGAPs is important for their functions
  • negatively regulates neuronal migration and induces neurite outgrowth and branching through the ability of its F-BAR domain to induce filopodia-like membrane protrusions resembling those induced by I-BAR domains
  • regulates neuronal morphogenesis through the ability of its F-BAR domain to regulate membrane deformation and induce filopodia formation
  • implicated in neocortical development
  • is enriched at excitatory synapses
  • promotes spine maturation and limits spine density andco-regulates spine density with the length of spine neck
  • regulates neurite outgrowth and neuronal migration by causing membrane protrusions reminiscent of the activity of I-BAR domain proteins
  • SRGAP2 signaling network as a key regulator of contact inhibition of locomotion (CIL) in fibroblasts
  • specifically controls the duration of RAC1 activity in contact protrusions, but not in contact-free protrusions
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with the intracellular domain of ROBO1
  • physically interacts with protein arginine methyltransferase 5 (PRMT5)
  • after RAC1-dependent activation of FMNL1, SRGAP2 mediates a potent mechanism to limit the duration of RAC1 action and inhibit formin activity during rapid actin dynamics
  • inhibition of SRGAP2 function by SRGAP2B, SRGAP2C has contributed to the evolution of the human neocortex and plays an important role during human brain development
  • function of ancestral SRGAP2 is conserved between mouse and human and is inhibited by SRGAP2C expression
  • interplay between SRGAP1, SRGAP2 and SRGAP3 regulates neuronal differentiation and neurite outgrowth
  • cell & other
    REGULATION
    activated by enhanced by SLIT*
    inhibited by inactivated by CDC42
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS