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FLASH GENE
Symbol SRGAP2 contributors: - updated : 27-04-2006
HGNC name SLIT-ROBO Rho GTPase-activating protein 2
HGNC id 19751
Location 1q32.1      Physical location : 206.516.199 - 206.637.782
Synonym name SH3-type formin binding protein 2
Synonym symbol(s) KIAA0456, FNBP2, srGAP3, ARHGAP14
DNA
TYPE functioning gene
STRUCTURE 121.00 kb     20 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary  lowly
Urinarykidney   lowly
cell lineage
cell lines in melanoma, germ cell tumors, chondrosarcoma and retinoblastoma
fluid/secretion
at STAGE
physiological period pregnancy
Text lowly in placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal FCH domain
  • a central RHO-GAP domain
  • a FBH and a HR1 doamains
  • a C terminal SH3 domain
  • HOMOLOGY
    intraspecies homolog to RHO-GAP hematopoietic protein C1(ARHGAP4)
    Homologene
    FAMILY
  • Rho GTPase family
  • FNBP2 family protein
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • axon guidance and neurite outgrowth
  • couplingmembrane deformation to actin cytoskeleton reorganization in various cellular processes
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with the intracellular domain of ROBO1
  • cell & other
    REGULATION
    activated by enhanced by SLIT*
    inhibited by inactivated by CDC42
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS