protein
| cleaved by MBTPS1 in the ER luminal loop between the two membrane spanning regions, initiating the two-step proteolytic process by which the N terminal of SREBF is translocated to nucleus |
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KPNB1 |
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down-regulating ABCA1 in vascular endothelial cells |
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interacting with HNF4A (potentiates the SREBP functions and stimulates expression of SREBP-responsive genes in enterohepatic cells)  |
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RNF139 hinders SREBPF2 processing through interaction with SREBPF2 and SCAP, regulating its own turnover rate by means of its E3 ubiquitin ligase activity  |
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SREBF2, a key transcription factor of cholesterol synthesis, interacted with the AACS promoter was increased during neurite outgrowth  |
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sterol sensor SCAP is a key regulator of SREBF2, the major transcription factor controlling cholesterol synthesis  |
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SIRT6 is a critical factor for SREBF2 gene regulation  |
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multimeric ER proteins ERLIN1 and ERLIN2 are additional SREBF1, SREBF2 regulators  |
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SREBPF2 negatively regulates the FXR-mediated transcriptional activation of the FGF19 gene in human intestinal cells  |
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FOXO4 interacts with SREBF2 and EPAS1 to modulate CYP51A1 promoter activity  |
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SREBF1, SREBF2 actively prevents premature recycling of SCAP-SREBF until initiation of SREBF cleavage  |