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FLASH GENE
Symbol SRD5A1 contributors: mct/npt - updated : 22-08-2008
HGNC name steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
HGNC id 11284
Location 5p15.31      Physical location : 6.633.499 - 6.669.673
Synonym name
  • 3-oxo-5-alpha-steroid 4-dehydrogenase 1
  • SR type 1
  • steroid 5-alpha-reductase type I
  • Synonym symbol(s) S5AR
    EC.number 1.3.99.5
    DNA
    TYPE functioning gene
    STRUCTURE 36.20 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    IRX2 5p15.3 iroquois homeobox protein 2 CEI 5p15.33 CEI protein LOC391734 5 similar to 3-hydroxyisobutyryl-Coenzyme A hydrolase isoform 1 LOC389268 5 LOC389268 LOC389269 5 LOC389269 IRX1 5p15.3 iroquois homeobox protein 1 LOC153297 5p15.33 hypothetical LOC153297 LOC340094 5p15.33 hypothetical protein LOC340094 ADAMTS16 5p15 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 16 KIAA0947 5p15.32 KIAA0947 protein MGC5309 5p15.32 hypothetical protein MGC5309 LOC134111 5p15.32 similar to 3110006E14Rik protein LOC389270 5 LOC389270 FLJ20303 5p15.32 hypothetical protein FLJ20303 SRD5A1 5p15.31 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) POLS 5p15 polymerase (DNA directed) sigma LOC391735 5 similar to hypothetical protein FLJ36144 ADCY2 5p15.33-p15.31 adenylate cyclase 2 (brain) MGC5297 5p15.3-p15.2 hypothetical protein MGC5297 MTRR 5p15.31 5-methyltetrahydrofolate-homocysteine methyltransferase reductase SEMA5A 5p15-pter sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A TAS2R1 5p15.2 taste receptor, type 2, member 1 LOC389271 5 LOC389271 LOC134145 5p15.31 hypothetical protein LOC134145 CCT5 5p15.2 chaperonin containing TCP1, subunit 5 (epsilon) LOC134147 5p15.31 hypothetical protein BC001573 TEB4 5p15.2 similar to S. cerevisiae SSM4 ASP 5p15.31 AKAP-associated sperm protein LOC389272 5 LOC389272
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2285 29 259 - Liu (2008)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Endocrineadrenal gland   highly
    Reproductivefemale systemuteruscervix highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • steroid 5-alpha reductase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • playing a pivotal role in the action of androgens on target organs
  • catalyzing the conversion of testosterone to dihydrotestosterone
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in recurrent and metastatic prostate cancers
    Susceptibility to polycystic ovary syndrome (PCOS) with hirsutism
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS