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FLASH GENE
Symbol SRCIN1 contributors: mct - updated : 12-01-2018
HGNC name SRC kinase signaling inhibitor 1
HGNC id 29506
Location 17q12      Physical location : 36.686.259 - 36.762.183
Genatlas name SNAP25-interacting protein
Synonym name
  • p130Cas-associated protein
  • SNAP25-interacting protein
  • p140Cap
    • Synonym symbol(s) KIAA1684, p140Cap, SNIP
    DNA
    TYPE functioning gene
    STRUCTURE 77.15 kb     19 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 7050 - 1183 - 2004 14657239
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepancreas exocrine   highly
    Nervousbrain   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophilic
    STRUCTURE
    motifs/domains
  • two predicted coiled-coil domains
  • two highly charged regions
  • two proline-rich domains with multiple PPXY and PXXP motifs
    • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to murine P140
    ortholog to rattus SNIP
    Homologene
    FAMILY
  • p140Cap family
    • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • delaying the onset of cell spreading in the early stages of cell adhesion to fibronectin
  • involved in calcium- dependent exocytosis from PC12 cells
  • playing a role in controling actin cytoskeleton organization in response to adhesive and growth factor signaling
  • involved in regulation of neurosecretion, perhaps via its interaction with SNAP-25 and the cytoskeleton
  • is an adaptor protein considered to play pivotal roles in cell adhesion, growth and SRC tyrosine kinase-related signaling in non-neuronal cells
  • is likely involved in neurotransmitter release, synapse formation/maintenance, and signaling
  • Src-binding protein that regulates Src activation through C-terminal Src kinase (Csk)
  • mechanistically behaves as a tumour suppressor that inhibits signalling pathways leading to aggressive phenotypes
  • regulates tumor properties in terms of cell motility and growth
  • suppresses the invasive properties of highly metastatic breast carcinoma cells by inhibiting cortactin-dependent cell motility
  • played a tumor suppressor role in the development of lung cancer and breast cancer
  • acted as a tumor suppressor gene in the development of osteosarcoma
  • adaptor protein SRCIN1 is a novel SRC-binding protein that regulates SRC activation through C-terminal SRC kinase (Csk)
  • SRCIN1 contributes to colorectal carcinogenesis, invasion and metastasis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport
    PATHWAY
    metabolism
    signaling
    a component
  • tyrosine-phosphorylated
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • suppresses the invasive properties of highly metastatic breast carcinoma cells by inhibiting cortactin-dependent cell motility
  • SNAP25 likely allows the organization of the molecular apparatus needed for spine formation by recruiting and stabilizing SRCIN1
  • regulates memory and synaptic plasticity through SRC-mediated and CIT-N-mediated actin reorganization
  • SRCIN1, a regulator of cytoskeleton reorganization, is a downstream effector of SH3GL2 and disruption of their interaction impairs spine formation and maturation
  • presynaptic CTNNB1 expression enhanced release probability of glutamatergic synapses, and newly identified CTNNB1-interacting protein SRCIN1 is required in the presynaptic locus for mediating these effects
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS