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FLASH GENE

Symbol

SRCAP

contributors: mct/pgu - updated : 15-02-2012

HGNC name	Snf2-related CREBBP activator protein
HGNC id	16974

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	FLHS Floating-Harbor syndrome
Location	16p11.2      Physical location : 30.710.461 - 30.751.449
Genatlas name	Snf2-related CBP activator protein
Synonym name	cDNA sequence, expressed in brain, >100kDa, related to 218kDa MI2
Synonym symbol(s)	KIAA0309, DOMO1, EAF1, FLJ44499, SWR1

DNA

TYPE	functioning gene
STRUCTURE	40.98 kb     34 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Physical map

RNA

TRANSCRIPTS	type

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006662 34 - 10491 - 3230 - 2007 17617668

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly   salivary gland       highly Nervous brain         Reproductive male system prostate     highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier lining uroepithelium     Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Reproductive epithelial cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

N-terminal region binding to H2AFZ and containing the helicase-SANT-associated (HSA) domain, critical for protein association, including association of actin and actin-related proteins (Wu 2009)

mono polymer

heptamer

HOMOLOGY

interspecies

homolog to drosophila Dom

intraspecies

homolog to 218kDa MI2

Homologene

FAMILY

SNF2 ATPase family

CATEGORY

enzyme , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,nucleus,chromatin/chromosome,nucleosome

basic FUNCTION	SNF2-related helicase, functioning as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM1 and NCOA2
	functioning as a glucocorticoid receptor coactivator
	ATPase chromatin-remodeling machine, implicated in the transcriptional coactivation of cyclic AMP- and steroid-dependent promoters
	SRCAP complex catalyzes ATP-dependent exchange of histone H2A/H2B dimers containing the histone variant H2A.Z into nucleosomes
	having a coactivator function that may depend on its ability to promote incorporation of H2AFZ into chromatin
	could catalyze deposition of H2AFZ into nucleosomes
	recruited to promoters and is critical for the deposition of H2AFZ
	ATPase that is the core subunit of a large multiprotein complex and was shown to incorporate the histone variant H2A.Z into nucleosomes
	serves as a coactivator for several nuclear receptors including the androgen receptor (AR)
	activates hormone-dependent transcription of the androgen responsive, prostate specific antigen (PSA)-Luciferase reporter gene in human prostate cells
	plays a role in prostate cancer cell proliferation
	SNF2-related chromatin-remodeling factor that serves as a coactivator for CREB-binding protein (CREBBP)
	undergoes a large conformational change upon nucleosome binding (pMID: 24034246)

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

function in the notch signaling pathway

a component	part of a multiprotein complex, SRCAP-containing complex supporting ATP-dependent exchange of histone dimers containing H2B and H2AFZ into mononucleosomes reconstituted with recombinant H2A, H2B, H3, and H4
	a single heterohexameric RVB1/RVB2 ring that, together with the catalytic subunit SWR1, brackets two independently assembled multisubunit modules

INTERACTION

DNA

RNA

small molecule

protein	with CBP (cAMP response element binding protein), functioning as a coactivator to regulate transcription initiated by several signaling pathways
	functionally interacts with NCOA2 and CARM1
	potent coactivator for CREB and CBP-mediated transcription
	interacting with Hepatitis C virus NS3 protein (can activate the Notch-signaling pathway through binding to SRCAP)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

FLHS

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS