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FLASH GENE
Symbol SRCAP contributors: mct/pgu - updated : 15-02-2012
HGNC name Snf2-related CREBBP activator protein
HGNC id 16974
Corresponding disease
FLHS Floating-Harbor syndrome
Location 16p11.2      Physical location : 30.710.461 - 30.751.449
Genatlas name Snf2-related CBP activator protein
Synonym name cDNA sequence, expressed in brain, >100kDa, related to 218kDa MI2
Synonym symbol(s) KIAA0309, DOMO1, EAF1, FLJ44499, SWR1
DNA
TYPE functioning gene
STRUCTURE 40.98 kb     34 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC387619 16 PI-3-kinase-related kinase SMG-1 LOC390689 16 similar to carbonic anhydrase VA, mitochondrial precursor; carbonic anhydrase V, mitochondrial; carbonic dehydratase CD2BP2 16p12.1 CD2 antigen (cytoplasmic tail) binding protein 2 DKFZP434P1750 16p12.1 DKFZP434P1750 protein HUMMLC2B 16p12.1 myosin light chain 2 SEPT1 16q11.1 septin 1 FLJ31751 16p12.1 hypothetical protein FLJ31751 LOC51333 16p12.1 mesenchymal stem cell protein DSC43 XTP3TPA 16p12.1 XTP3-transactivated protein A SEPHS2 16p12.1 selenophosphate synthetase 2 ITGAL 16p11.2 integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) FLJ23436 16p11.2 hypothetical protein FLJ23436 MGC2474 16p11.2 hypothetical protein MGC2474 LOC388244 16 LOC388244 MGC13138 16p11.2 hypothetical protein MGC13138 LOC146542 16p11.2 similar to hypothetical protein MGC13138 FLJ32130 16p11.2 hypothetical protein FLJ32130 LOC115509 16p11.2 hypothetical protein BC014000 MGC3121 16p11.2 hypothetical protein MGC3121 FBS1 16p11.2 fibrosin 1 LOC388245 16 LOC388245 SRCAP 16p11.2 LOC388245 PHKG2 16p11.2-p12.1 phosphorylase kinase, gamma 2 (testis) LOC388246 16 LOC388246 RNF40 16p11.2-p11.1 ring finger protein 40 KIAA0326 16p11 ring finger protein 40 LOC390690 16 similar to Protein C20orf27 BCL7C 16p11 B-cell CLL/lymphoma 7C CTF1 16p11.2-p11.1 cardiotrophin 1 LOC283932 16p11.2 hypothetical protein LOC283932 MGC13024 16p11.2 hypothetical protein MGC13024 KIAA0339 16p11 hypothetical protein MGC13024 HSD3B7 16p11.2-12 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 STX1B2 16p12-p11 syntaxin 1B2 STX4A 16p13.13-p12.3 syntaxin 4A (placental) FLJ13479 16p11.2 hypothetical protein FLJ13479 KIAA0296 16p13.13-p13.2 hypothetical protein FLJ13479 IMAGE3455200
RNA
TRANSCRIPTS type
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
34 - 10491 - 3230 - 2007 17617668
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 salivary gland   highly
Nervousbrain    
Reproductivemale systemprostate  highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier lininguroepithelium   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductiveepithelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal region binding to H2AFZ and containing the helicase-SANT-associated (HSA) domain, critical for protein association, including association of actin and actin-related proteins (Wu 2009)
  • mono polymer heptamer
    HOMOLOGY
    interspecies homolog to drosophila Dom
    intraspecies homolog to 218kDa MI2
    Homologene
    FAMILY SNF2 ATPase family
    CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,chromatin/chromosome,nucleosome
    basic FUNCTION
  • SNF2-related helicase, functioning as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM1 and NCOA2
  • functioning as a glucocorticoid receptor coactivator
  • ATPase chromatin-remodeling machine, implicated in the transcriptional coactivation of cyclic AMP- and steroid-dependent promoters
  • SRCAP complex catalyzes ATP-dependent exchange of histone H2A/H2B dimers containing the histone variant H2A.Z into nucleosomes
  • having a coactivator function that may depend on its ability to promote incorporation of H2AFZ into chromatin
  • could catalyze deposition of H2AFZ into nucleosomes
  • recruited to promoters and is critical for the deposition of H2AFZ
  • ATPase that is the core subunit of a large multiprotein complex and was shown to incorporate the histone variant H2A.Z into nucleosomes
  • serves as a coactivator for several nuclear receptors including the androgen receptor (AR)
  • activates hormone-dependent transcription of the androgen responsive, prostate specific antigen (PSA)-Luciferase reporter gene in human prostate cells
  • plays a role in prostate cancer cell proliferation
  • SNF2-related chromatin-remodeling factor that serves as a coactivator for CREB-binding protein (CREBBP)
  • undergoes a large conformational change upon nucleosome binding (pMID: 24034246)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    function in the notch signaling pathway
    a component
  • part of a multiprotein complex, SRCAP-containing complex supporting ATP-dependent exchange of histone dimers containing H2B and H2AFZ into mononucleosomes reconstituted with recombinant H2A, H2B, H3, and H4
  • a single heterohexameric RVB1/RVB2 ring that, together with the catalytic subunit SWR1, brackets two independently assembled multisubunit modules
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with CBP (cAMP response element binding protein), functioning as a coactivator to regulate transcription initiated by several signaling pathways
  • functionally interacts with NCOA2 and CARM1
  • potent coactivator for CREB and CBP-mediated transcription
  • interacting with Hepatitis C virus NS3 protein (can activate the Notch-signaling pathway through binding to SRCAP)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FLHS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS