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FLASH GENE
Symbol SRA1 contributors: shn/npt - updated : 16-05-2009
HGNC name steroid receptor RNA activator 1
HGNC id 11281
Location 5q31.3      Physical location : 139.929.653 - 139.937.678
Synonym name
  • steroid receptor RNA activator protein, SRAP
  • steroid receptor coactivator
  • steroid receptor RNA activator 1 (complexes with NCOA1)
  • Synonym symbol(s) SRA, SRAP, STRAA1, pp7684, MGC87674
    DNA
    TYPE functioning gene
    STRUCTURE 8.03 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map cen - D5S2116 - D5S2009 - SRA - D5S658 - D5S2508 - qter
    Physical map
    PFDN1 5q31-q32 prefoldin 1 DTR 5q23-q31 diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor) SLC4A9 5q31 solute carrier family 4, sodium bicarbonate cotransporter, member 9 FLJ20288 SLC35A4 5q31.3 solute carrier family 35, member A4 EIF4EBP3 5q31.3 eukaryotic translation initiation factor 4E binding protein 3 SRA1 5q31.3 steroid receptor RNA activator 1 APBB3 5q31 amyloid beta (A4) precursor protein-binding, family B, member 3 CD14 5q31.1 CD14 antigen PRO1580 5q31.3 hypothetical protein PRO1580 NDUFA2 5q31.2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa IK 2p15-p14 IK cytokine, down-regulator of HLA II FLJ20195 5q31.3 hypothetical protein FLJ20195 DND1 5q31.3 dead end homolog 1 (zebrafish) HARS 5q31.1 histidyl-tRNA synthetase HARSL 5q31.1-q33.2 histidyl-tRNA synthetase-like FLJ31121 5q31.3 hypothetical protein FLJ31121 PCDHA1 5q31.3 protocadherin alpha 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1965 - 236 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Endocrinepancreas   moderately
    Nervousbrain   lowly
    Reproductivefemale systemplacenta  moderately
    Respiratorylung   moderately
    Urinarykidney   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage in normal and tumorigenic breast epithelial cell lines
    cell lines A549, HeLa, HepG2, LNCaP, MCF7, T-47D, 293
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal transactivation domain
  • SRA exists in distinct ribonucleoprotein complexes
  • a thyroid hormone receptor binding domain
  • a zinc finger domain
  • a ligand binding domain
  • HOMOLOGY
    interspecies ortholog to sra1, Danio rerio
    ortholog to Sra1, Mus musculus
    ortholog to Sra1, Rattus norvegicus
    Homologene
    FAMILY
  • SRA1 family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    text
  • PUS3 an SRA1 are mainly cytoplasmic, but are also localized in distinct nuclear subcompartments
  • in breast cancer cells, detected both in the cytoplasm and the nucleus
  • basic FUNCTION
  • involved in transcriptional coactivation by steroid receptors
  • enhances cellular proliferation and differentiation and promotes apoptosis
  • SRA may act to confer functional specificity upon multiprotein complexes recruited by liganded receptors during transcriptional activation
  • may play a role in tumorigenesis
  • play a role in steroidogenesis and adrena biology
  • can function as a RNA
  • coactivates glucortcoid, retinoic acid receptors and the muscle differentiation factor MyoD
  • functions as a thyroid hormone receptor coactivator
  • plays a critical role in nuclear hormone receptor activity
  • plays an important role in the expression of StAR and Mc2R genes
  • SRA is important to stabilize complexes of SF-1 and Dax-1 for the recruitment of p160 coactivators to regulate target gene expression in steroidogenesis
  • PUS1 and PUS3 -dependent pseudouridylation of SRA1 is a highly complex posttranscriptional mechanism that controls a coactivator-corepressor switch in SRA1 with major consequences for NR signaling
  • has the ability to modulate the action of steroid receptors (ESR1, AR and GR) likely through direct interactions
  • as its RNA, has the potential to be involved in many critical pathways and putatively directly participates to the regulation of gene expression
  • play a crucial role in nuclear receptor transcriptional regulation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component DDX5/SRA1 stabilizes the interaction of cohesin with CTCF by binding to both, and is required for proper insulator function
    INTERACTION
    DNA
    RNA noncoding RNA SRA
    small molecule
    protein
  • MyoD
  • DAX1
  • physically interacts with multiple transcription factors and is recruited to specific promoter regions (more strongly interact with ESR2 than with ESR1)
  • SPEN association with SRA1 relies on both single- and double-stranded RNA sequences
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS