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FLASH GENE
Symbol SPTSSB contributors: mct - updated : 22-12-2016
HGNC name serine palmitoyltransferase small subunit B
HGNC id 24045
Location 3q26.1      Physical location : -
Synonym name
  • androgen down regulated gene
  • chromosome 3 open reading frame 57
  • Synonym symbol(s) ADMP, MGC104229, C3orf57, SSSPTB
    DNA
    TYPE functioning gene
    STRUCTURE 28.34 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 3321 - 76 - 2005 15777716
    3 - 2306 - 76 - 2005 15777716
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus    
    Nervousbrain    
    Reproductivefemale systembreastmammary gland  
     male systemprostate    Homo sapiens
    Respiratoryrespiratory tracttrachea   
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductiveepithelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to a putative G-protein coupled receptor
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • shares sequence similarity to a putative G-protein coupled receptor indicating its possible role in signal transduction
  • SPTSSA, SPTSSB share a conserved hydrophobic central domain predicted to reside in the membrane, and each interacts with both SPTLC1 and SPTLC2
  • serine palmitoyltransferase (SPT) small subunits (SPTSSA, SPTSSB) play a major role in controlling SPT activity and substrate affinity, and in specifying sphingolipid long chain base (LCB) chain length
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with both SPTLC1 and SPTLC2
  • cell & other
    REGULATION
    inhibited by androgens
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS