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FLASH GENE
Symbol SPTBN5 contributors: - updated : 03-09-2007
HGNC name spectrin, beta, non-erythrocytic 5
HGNC id 15680
Location 15q21      Physical location : 42.140.344 - 42.186.275
Synonym symbol(s) BSPECV,HUBSPECV
DNA
TYPE functioning gene
STRUCTURE 45.00 kb     68 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
RAD51 15q15.1 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) FLJ10579 15q14 hypothetical protein FLJ10579 GCHFR 15q15 GTP cyclohydrolase I feedback regulatory protein FLJ10634 15q14 hypothetical protein FLJ10634 ZFYVE19 15q14 zinc finger, FYVE domain containing 19 PPP1R14D 15q13.3 protein phosphatase 1, regulatory (inhibitor) subunit 14D SPINT1 15q15 serine protease inhibitor, Kunitz type 1 ARHV 15q13.3 ras homolog gene family, member V VPS18 15q14-q15 vacuolar protein sorting protein 18 DLL4 15q14 delta-like 4 (Drosophila) MGC4504 15q14 hypothetical protein MGC4504 KIAA1259 15q14 hypothetical protein MGC4504 HCP37 15q15.1 cytochrome c, somatic pseudogene LOC388116 15 similar to RIKEN cDNA 6720467C03 MGC33637 15q14 hypothetical protein MGC33637 CHP 15q13.3 hypothetical protein MGC33637 OIP5 15q14 Opa-interacting protein 5 NUSAP1 15q14 nucleolar and spindle associated protein 1 CIA30 KIAA0252 15q14 nucleolar and spindle associated protein 1 ITPKA 15q14-q21 inositol 1,4,5-trisphosphate 3-kinase A LTK 15q15.1-q15.2 leukocyte tyrosine kinase DKFZP727M111 15q14 DKFZP727M111 protein LOC283747 15q14 similar to elongation factor SIII p15 subunit TYRO3 15q15.1-q21.1 TYRO3 protein tyrosine kinase MGA 15q15 MAX gene associated MAPKBP1 15q14 likely ortholog of mouse mitogen activated protein kinase binding proten 1 PLA2G4B 15q11.2-q21.3 phospholipase A2, group IVB (cytosolic) SPTBN5 15q21 spectrin, beta, non-erythrocytic 5 EHD4 15q11.1-q15 EH-domain containing 4 FLJ45651 15q14 FLJ45651 protein LOC388117 15 LOC388117 cPLA2delta LOC255189 15q14 hypothetical protein LOC255189 VPS39 15q14-q15 vacuolar protein sorting 39 (yeast) DKFZP564G2022 15q14 DKFZP564G2022 protein GANC 15q15.1-q15.2 glucosidase, alpha; neutral C CAPN3 15q15.1-q15.3 calpain 3, (p94) ZFP106 15q14 zinc finger protein 106 homolog (mouse) SNAP23 15q14-q15.1 synaptosomal-associated protein, 23kDa FLJ36812 15q14 hypothetical protein FLJ36812 FLJ10460 15q14 hypothetical protein FLJ10460 LOC390579 15 similar to myosin regulatory light chain-like LOC388118 15 similar to kinesin-like protein STARD9 15q14 START domain containing 9 CDAN1 15q14-q15 congenital dyserythropoietic anemia, type I TTBK2 15q14 tau tubulin kinase 2 LOC390580 15 similar to Ac2-125
RNA
TRANSCRIPTS type messenger
text the first exon may be alternatively spliced
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   highly
 mouth    
 salivary gland    
 stomach   highly
endocrinebraindiencephalonpituitary highly
Endocrinepancreas   highly
Nervousbrain   highly
 brainhindbraincerebellum highly
 spinal cord   highly
Urinarybladder   highly
 kidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
thirty spectrin repeats,an actin-binding domain,a membrane association domain one,a self association and a pleckstrin homology domains near the C terminus
mono polymer heteromer , dimer , polymer
HOMOLOGY
interspecies ortholog to Drosophila beta heavy spectrin
Homologene
FAMILY
CATEGORY structural protein
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,cytoskeleton
text
  • actin cytoskeleton associated
  • vesicles of the secretory/endocytic pathway
  • basic FUNCTION
  • cell structure
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heterodimers and oligomers with alpha spectrin
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • actin
  • cell & other
  • interact directly with cellular mempbranes
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS