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FLASH GENE
Symbol SPSB3 contributors: SGE/npt - updated : 02-10-2009
HGNC name splA/ryanodine receptor domain and SOCS box containing 3
HGNC id 30629
Location 16p13.3      Physical location : 1.826.713 - 1.832.581
Synonym name
  • SPRY domain-containing SOCS box protein SSB-3
  • chromosome 16 open reading frame 31
  • Synonym symbol(s) SSB3, C16orf31
    DNA
    TYPE functioning gene
    STRUCTURE 5.80 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1553 39 355 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepancreas exocrine   highly
     stomach   highly
    Lymphoid/Immunelymph node   highly
    Nervousbrain   moderately
    Reproductivefemale systemuteruscervix moderately
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one B30.2/SPRY domain
  • one SOCS domain
  • HOMOLOGY
    interspecies homolog to murine Spsb3 (89.3pc)
    homolog to rattus Spsb3 (89.6pc)
    Homologene
    FAMILY
  • SPSB family
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • involved in intracellular signaling cascade
  • may be a substrate recognition component of SCF-like ECS E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins
  • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • interacting with the Elongin BC complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with MET
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS