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FLASH GENE
Symbol SPSB1 contributors: mct - updated : 28-12-2006
HGNC name splA/ryanodine receptor domain and SOCS box containing 1
HGNC id 30628
Location 1p36.22      Physical location : 9.352.940 - 9.429.588
Genatlas name SPRY domain-containing SOCS box protein SSB-1
Synonym symbol(s) RP3-324M8.1, SSB-1, SSB1
DNA
TYPE functioning gene
STRUCTURE 76.00 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
 pancreas exocrine   highly
Endocrinethyroid   highly
Reproductivefemale systemovary  highly
 female systemplacenta  highly
Respiratorylung   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a central SPRY domain
  • a C-terminal SOCS box
    • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
  • suppressor of cytokine signaling (SOCS) protein family
  • SPRY (repeats in splA and RyR) domain-containing SOCS box protein (SSB) subfamily
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • may play an important role in enhancing the HGF-induced Erk-Elk-1-SRE pathway
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    intracellular signaling cascade
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacts with MET(bound to MET tyrosine kinase domain through its SPRY domain, in both the absence and the presence of HGF)
    cell & other
    REGULATION
    Other in response to HGF stimulation, became phosphorylated at tyrosine residue 31
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS