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FLASH GENE
Symbol SPRY3 contributors: npt - updated : 03-02-2012
HGNC name sprouty homolog 3 (Drosophila)
HGNC id 11271
Location Xq28      Physical location : 59.100.456 - 155.012.117
Genatlas name see also SPRY3Y
Synonym name
  • Drosophila sprouty homolog, X-linked, located on the long arm pseudoautosomal (PARYQ) region
  • antagonist of FGF signaling
  • Synonym symbol(s) HSPRY3, SPRY3X, Spry-3
    DNA
    TYPE functioning gene
    STRUCTURE 14.67 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map see SYBL1
    regionally located located on the long arm pseudoautosomal (PARYQ) region, in the proximal 295kb, undergoing X (and Y) inactivation
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 9038 - 288 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Endocrinepancreas   highly
    Reproductivemale systemprostate  highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text particularly in tissues
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a cys-rich domain is responsible for the localization to the membrane ruffles
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to Drosophila sprouty
    Homologene
    FAMILY
  • SPROUTY family
  • CATEGORY regulatory , signaling cytokine
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text in the cytoplasm in unstimulated cells
  • translocated in the membrane ruffles in cells stimulated with EGF (epidermal growth factor)
  • basic FUNCTION
  • palmitoylated phosphoproteins that can attenuate or potentiate numerous growth factor-induced signaling pathways
  • involved in determining apical branching of airways (negative modulation of respiratory organogenesis)
  • putative inhibitor of FGF signaling and regulator of RAS signaling
  • SPRY1, SPRY2, SPRY3, SPRY4, are central and complex regulators of the receptor tyrosine kinase (RTK) signalling pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text histogenesis and organogenesis
    PATHWAY
    metabolism
    signaling signal transduction
    FGF signaling antagonist
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CAV1 (C terminus of CAV1 is the major Sprouty-binding site, whereas Sprouty binds CAV1 via its conserved C-terminal domain, and interaction modulates signaling in a growth factor- and Sprouty isoform-specific manner)
  • cell & other
    REGULATION
    induced by FGF signaling
    Other undergoing X inactivation
    silencing of SPRY3, appears to be independent of DNA methylation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS