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FLASH GENE
Symbol SPRY1 contributors: mct/pgu - updated : 22-08-2014
HGNC name sprouty homolog 1, antagonist of FGF signaling (Drosophila)
HGNC id 11269
Location 4q28.1      Physical location : 124.317.955 - 124.324.907
Synonym name protein sprouty homolog 1
DNA
TYPE functioning gene
STRUCTURE 6.96 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
PRDM5 4q27 PR domain containing 5 FLJ23191 4q27 hypothetical protein FLJ23191 TNIP3 4q27 TNFAIP3 interacting protein 3 GPR103 4q27 G protein-coupled receptor 103 LOC391692 4 similar to TUBULIN BETA CHAIN ANXA5 4q26-q27 annexin A5 FLJ30834 4q27 hypothetical protein FLJ30834 PMSCL1 4q27 polymyositis/scleroderma autoantigen 1, 75kDa CCNA2 4q27 cyclin A2 BBS7 4q27 Bardet-Biedl syndrome 7 TRPC3 4q25-q27 transient receptor potential cation channel, subfamily C, member 3 KIAA1109 4q28.1 hypothetical protein KIAA1109 Tenr 4q28.1 testis nuclear RNA-binding protein IL2 4q26-q27 interleukin 2 IL21 4q26-q27 interleukin 21 FLJ35630 4q28.1 hypothetical protein FLJ35630 FGF2 4q26 fibroblast growth factor 2 (basic) NUDT6 4q26 nudix (nucleoside diphosphate linked moiety X)-type motif 6 SPATA5 4q27 spermatogenesis associated 5 SPRY1 4q26-q27 sprouty homolog 1, antagonist of FGF signaling (Drosophila) LOC391693 4 similar to ribosomal protein L21 LOC391694 4 similar to Peptidylprolyl isomerase A (cyclophilin A) LOC391695 4 similar to Tubulin alpha-4 chain (Alpha-tubulin 4) LOC391696 4 similar to Synaptic glycoprotein SC2 KIAA1223 4q28.1 KIAA1223 protein LOC339951 4q28.1 similar to ENSANGP00000007226 FLJ23056 4q28.1 hypothetical protein FLJ23056
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 splicing 2612 35.1 319 - 2002 12402043
2 splicing 2349 35.1 319 - 2002 12402043
having a C-terminal cysteine-rich region
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
 vessel   moderately
Digestiveintestinelarge intestinecolon highly
 mouthtongue  highly
 pancreas exocrine   highly
 stomach   moderately
Lymphoid/Immunethymus   highly
Reproductivefemale systembreastmammary gland moderately
 male systemprostate    Rattus norvegicusFetal
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
not specificchondrocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • cysteine-rich protein
  • a SPR (sprouty) domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to Drosophila sprouty
    ortholog to rattus Spry1_predicted
    ortholog to murine Spry1
    Homologene
    FAMILY
  • sprouty family
  • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text
  • lamellipodium
  • found in the cytoplasm in unstimulated cells
  • translocated to the membrane ruffles in cells stimulated with EGF
  • basic FUNCTION
  • palmitoylated phosphoprotein that can attenuate or potentiate numerous growth factor-induced signaling pathways
  • may function as an antagonist of fibroblast growth factor (FGF) pathways
  • may negatively modulate respiratory organogenesis
  • induced by TCR signal, and negatively regulates further TCR signaling by interacting with proximal signaling molecules in immune synapse
  • inhibits angiogenesis in association with up-regulation of CDKN1A, CDKN1B
  • critical regulator of adipocyte differentiation and mesenchymal stem cell (MSC) lineage allocation, potentially acting through regulation of CEBPB and TAZ
  • is potentially an important regulator of craniofacial and cardiac morphogenesis and perturbations in SPRY1 levels may contribute to congenital disorders involving tissues of neural crest origin
  • endogenous angiogenesis inhibitor
  • playing a role in the regulation of signal transduction
  • negatively regulates primitive hematopoiesis and endothelial cell function
  • SPRY1, SPRY2, SPRY3, SPRY4, are central and complex regulators of the receptor tyrosine kinase (RTK) signalling pathway
  • cytoplasmic localized cellular target for E1A oncoproteins to regulate the RTK signalling pathway, and consequently cellular events downstream of RTK that are essential for viral replication and transformation
  • SPRY1, SPRY2, are targets of FGF signaling in the lens during initiation of fiber differentiation and function redundantly in the corneal epithelial cells to suppress proliferation
  • is a candidate tumor-suppressor gene in medullary thyroid carcinoma
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CAV1 (C terminus of CAV1 is the major Sprouty-binding site, whereas Sprouty binds CAV1 via its conserved C-terminal domain, and interaction modulates signaling in a growth factor- and Sprouty isoform-specific manner)
  • with Sprouty2 bind to the adaptor protein CRKL in a stimulus-dependent manner
  • SPRY1 and SPRY2, associate with the HECT domain family E3 ubiquitin ligase, NEDD4
  • FGF13 regulates proliferation and differentiation of skeletal muscle by down-regulating SPRY1
  • cell & other
    REGULATION
    induced by FGF signaling
    hypoxia (hypoxia stimulates SPRY1 expression)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    activated in clear cell renal carcinoma
    tumoral     --low  
    DNA methylation in the promoter region is responsible for downregulating SPRY1 expression in prostate cancer
    tumoral     --low  
    SPRY1 promoter is frequently methylated in medullary thyroid carcinoma and its expression is consequently decreased
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS