basic FUNCTION
| palmitoylated phosphoprotein that can attenuate or potentiate numerous growth factor-induced signaling pathways |
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may function as an antagonist of fibroblast growth factor (FGF) pathways |
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may negatively modulate respiratory organogenesis |
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induced by TCR signal, and negatively regulates further TCR signaling by interacting with proximal signaling molecules in immune synapse |
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inhibits angiogenesis in association with up-regulation of CDKN1A, CDKN1B |
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critical regulator of adipocyte differentiation and mesenchymal stem cell (MSC) lineage allocation, potentially acting through regulation of CEBPB and TAZ |
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is potentially an important regulator of craniofacial and cardiac morphogenesis and perturbations in SPRY1 levels may contribute to congenital disorders involving tissues of neural crest origin |
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endogenous angiogenesis inhibitor |
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playing a role in the regulation of signal transduction |
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negatively regulates primitive hematopoiesis and endothelial cell function |
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SPRY1, SPRY2, SPRY3, SPRY4, are central and complex regulators of the receptor tyrosine kinase (RTK) signalling pathway |
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cytoplasmic localized cellular target for E1A oncoproteins to regulate the RTK signalling pathway, and consequently cellular events downstream of RTK that are essential for viral replication and transformation |
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SPRY1, SPRY2, are targets of FGF signaling in the lens during initiation of fiber differentiation and function redundantly in the corneal epithelial cells to suppress proliferation |
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is a candidate tumor-suppressor gene in medullary thyroid carcinoma |