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FLASH GENE
Symbol SPRN contributors: mct - updated : 17-10-2007
HGNC name shadow of prion protein homolog (zebrafish)
HGNC id 16871
Location 10q26.3      Physical location : 135.234.170 - 135.238.121
Synonym name shadow of prion protein
Synonym symbol(s) Sho, SHO, FLJ41197
DNA
TYPE functioning gene
STRUCTURE 40.00 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 3188 - 151 - Premzl (2004)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Endocrinethyroid   highly
Nervousbrainlimbic systemhippocampus  
Reproductivefemale systemovary  highly
Respiratorylung   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a highly conserved N-terminal signal sequence
  • Arg-rich basic region containing up to six tetrarepeats of consensus XXRG (where X is G, A or S)
  • a hydrophobic region of 20 residues with strong homology to PrP
  • a C-terminal peptide predicted to be a signal sequence for glycophosphotidylinositol (GPI)-anchor attachment, and a functionally conserved and ancient activity domain contributing to neuroprotection
  • HOMOLOGY
    interspecies homolog to PRNP
    Homologene
    FAMILY prion protein family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    text GPI anchored
    basic FUNCTION
  • playing a role in GTP binding
  • potential modulator for the biological actions of normal and abnormal PRNP
  • has neuroprotective properties
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein may interact either directly or indirectly with PRNP or its ligand (Campbell 2008)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    or low in prion infections
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS