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FLASH GENE
Symbol SPRED3 contributors: mct - updated : 23-02-2015
HGNC name sprouty-related, EVH1 domain containing 3
HGNC id 31041
Location 19q13.2      Physical location : 38.880.938 - 38.886.869
Synonym name
Synonym symbol(s) Eve-3, spred-3
DNA
TYPE functioning gene
STRUCTURE 9.90 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 5075 - 410 - 2003 12646235
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   specific SELECTED Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • in the N-terminus, a single Ena Vasp homology (EVH1) domain that can potently block activation of the Ras/MAPK pathway
  • a Sprouty-related cysteine-rich region (SPR domain) in the C-terminus
  • HOMOLOGY
    Homologene
    FAMILY sprouty family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may regulate growth factor-induced activation of the MAP kinase cascade
  • is specific in inhibiting the Ras/MAPK pathway
  • can block serum-mediated cell cycle progression and its expression is highly regulated during liver development
  • may act as an inhibitor of proliferation pathways in the mature liver and be involved in modulating the unique regenerative capacity of this organ
  • SPRED1, SPRED2, SPRED3 modulate growth factor receptor signaling by inhibiting the RAS-MAPK cascade
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RTK negative regulatory gene
  • GPM6A, and the Sprouty domain-containing proteins SPRED1 and SPRED3, are indeed palmitoylated by ZDHHC17
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS