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FLASH GENE
Symbol SPPL3 contributors: mct - updated : 14-09-2017
HGNC name signal peptide peptidase like 3
HGNC id 30424
Location 12q24.31      Physical location : 121.201.035 - 121.342.151
Genatlas name signal peptide peptidase 3
Synonym name
  • presenilin-like protein 4
  • intramembrane protease 2
  • Synonym symbol(s) IMP2, PSL4, PRO4332, MDHV1887, MGC90402, MGC126674, UNQ1887, MGC126676, DKFZp586C1324, PRO4332,
    EC.number 3.4.23.-
    DNA
    TYPE functioning gene
    STRUCTURE 141.00 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 3432 - 384 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Nervousbrainhindbrainmedulla oblongata  
     nervespinal nervesciatic highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal extensions are located in the extracellular space
  • a type I signal anchor sequence for initiation of protein translocation and membrane insertion
  • HOMOLOGY
    Homologene
    FAMILY
  • I-Clip family
  • peptidase A22B family
  • GxGD intramembrane proteases family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • having peptidase activity
  • cleave type II-oriented substrate peptides
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CLN5 is initially translated as a type II transmembrane protein and subsequently cleaved by SPPL3, into a mature soluble protein consisting of residues 93-407band the remaining N-terminal fragment is then cleaved by SPPL3 and SPPL2B and degraded in the proteasome
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS