protein
| interacting with SUFU and GLI1, GLI2, GLI3 (SUFU regulates GLI protein levels by antagonizing the activity of SPOP, a conserved GLI-degrading factor) |
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targets PDX1 for ubiquitination and proteasomal degradation |
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cullin 3 (CUL3)-based ubiquitin ligase, responsible for NCOA3 ubiquitination and proteolysis |
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CUL3, a component of E3 ubiquitin ligase, is a new binding partner of BRMS1 and the interaction between BRMS1 and CUL3 is mediated by the SPOP adaptor protein |
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DZIP1 regulates the stability of SPOP independent of its function in ciliogenesis |
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SPOP functions as a tumor suppressor to negatively regulate the stability of the ERG oncoprotein in prostate cancer |
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SPOP acts as a tumor suppressor by promoting senescence through degrading SENP7 |
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targets GlI2 and GLI3 for degradation and negatively regulates Hedgehog (Hh) signaling |
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novel regulation of SIRT2 by SPOP mediated degradation, which is important for the growth of lung tumor cells |
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SPOP is a tumor suppressor to down-regulate EGLN2 in prostate cancer |
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acts as an adaptor protein of the CUL3-RBX1 E3 ubiquitin ligase complex that generally recruits substrates for ubiquitination and subsequent degradation |
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SPOP recognizes a Ser/Thr (S/T)-rich motif in the C-terminal region of INF2 and triggers atypical polyubiquitination of INF2 |
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INF2 is important for SPOP inactivation-induced prostate cancer cell migration and invasion |