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FLASH GENE

Symbol

SPON2

contributors: SGE - updated : 22-02-2008

HGNC name	spondin 2, extracellular matrix protein
HGNC id	11253

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	4p16.3      Physical location : 1.160.721 - 1.166.980
Synonym name	differentially expressed in cancerous and noncancerous lung cells
Synonym symbol(s)	DIL1, DIL-1, M-spondin, Mindin

DNA

TYPE	functioning gene
STRUCTURE	5.00 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 6 - 1807 - 331 - Clark (2003)

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Endocrine pancreas         Lymphoid/Immune spleen       highly Nervous nerve       highly Reproductive male system prostate     highly Respiratory lung         Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid         Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Respiratory epithelial cell

cell lineage
cell lines	in cancerous lung cells lines (high expression)
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a hydrophobic signal sequence in the N terminus
	a FS1 and a FS2 domains
	a thrombospondin type I repeat (TSR1)

HOMOLOGY

interspecies

homolog to Drosophila mspo

intraspecies

homolog to homologous to the Mindin/F-spondin family

Homologene

FAMILY	mindin family
	spondin family

CATEGORY

immunity/defense , protooncogene

SUBCELLULAR LOCALIZATION	extracellular
text	secreted

basic FUNCTION	playing a role in axon guidance
	requierd for T-cell priming by dendritic cells (Li 2009)
	functioning as a pattern recognition molecule for initiating innate immune response (Li 2009)
	promoting activation of both adaptive and innate immune responses (Li 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

protein constituent of extracellular matrix

INTERACTION

DNA

RNA

small molecule	other,
	recognizing lipopolysaccharides (Li 2009)

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to autism spectrum disorder

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS