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FLASH GENE
Symbol SPON1 contributors: mct - updated : 02-10-2013
HGNC name spondin 1, (f-spondin) extracellular matrix protein
HGNC id 11252
Location 11p15.2      Physical location : 13.983.913 - 14.289.646
Synonym name
  • VSGP/F-spondin, vascular smooth muscle growth-promoting factor
  • spondin 1, (f-spondin)
    • Synonym symbol(s) KIAA0762, MGC10724, f-spondin, VSGP, VSGP/F-spondin,
    DNA
    TYPE functioning gene
    STRUCTURE 305.49 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D11S1307 - SPON1 - D11S1310 - MYOD1 - D11S902 - D11S921 - cen
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 5154 - 807 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinepancreas   highly
    Nervousnervecranial nerve  highly
    Reproductivemale systemprostate   
    Respiratoryrespiratory tracttrachea  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a FS domain found in F-spondins, mindins, M-spondin and amphiF-spondin, with a presence of three disulfide bonds associated with the N- and C-termini of the domain and a highly conserved N-linked glycosylation site
  • a reeler, a spondin and six thrombospondin type 1 repeat domains
    • HOMOLOGY
    interspecies homolog to rattus F-spondin (Rn.7546)
    homolog to Drosophila fat-spondin
    homolog to C.elegans F10E7.4
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may have a role in the growth and guidance of axons
  • promoting factor for cementoblastic differentiation
  • attaches to the extracellular matrix and promotes axonal outgrowth
  • is a novel protein in osteoarthritis (OA) cartilage, where it may act in situ at lesional areas to activate latent TGF-beta and induce cartilage degradation via pathways that involve production of PGE2
  • secreted and extracellular matrix-attached protein that has been implicated in axonal pathfinding during neural development as well as in vascular remodelling in adult tissues
  • multi-domain extracellular matrix (ECM) protein and a contact-repellent molecule that directs axon outgrowth and cell migration during development
  • cementoblast specific gene, which could promote periodontal ligament cell lines
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • downregulates recruitment to the root side of periodontal tissue via LRP8 and inhibits differentiation of osteoclastic precursors
  • regulates the differentiation of cementoblast-like cell lines via BMP7 expression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    aberrantly expressed in ovarian carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • positional candidate gene in blood pressure control in hypertensive humans
    • Marker
    Therapy target
    ANIMAL & CELL MODELS