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FLASH GENE
Symbol SPOCK3 contributors: mct - updated : 30-01-2006
HGNC name sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
HGNC id 13565
Location 4q32.3      Physical location : 167.654.535 - 168.155.741
Synonym name testican 3
Synonym symbol(s) TES-3, HSAJ1454, testican-3
DNA
TYPE functioning gene
SPECIAL FEATURE escaping inactivation
STRUCTURE 501.00 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
FLJ31659 4q32.3 hypothetical protein FLJ31659 LOC391712 4 similar to ring finger protein 129 LOC391713 4 similar to ring finger protein 129 RNF129 4q32.3 ring finger protein 129 LOC391714 4 similar to ring finger protein 129 FLJ38482 4q32.3 hypothetical protein FLJ38482 KLHL2 4q21.2 kelch-like 2, Mayven (Drosophila) GKP3 4q32.1 glycerol kinase pseudogene 3 SC4MOL 4q32-q34 sterol-C4-methyl oxidase-like CPE 4q31 carboxypeptidase E HADHAP 4q32 hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase pseudogene (gastrin binding protein pseudogene) LOC285507 4q32.3 similar to chromosome 9 open reading frame 34 LOC391715 4 similar to RING finger protein 15 (Zinc finger protein RoRet) (Tripartite motif-containing protein 38) TLL1 4q32-q33 tolloid-like 1 SPOCK3 4q32.3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 ANXA10 4q33 annexin A10 FLJ20035 4q32.3 hypothetical protein FLJ20035 FLJ31033 4q32.3 hypothetical protein FLJ31033 LOC285510 4q32.3 similar to hypothetical protein FLJ20035 KIAA0992 4q32.3 similar to hypothetical protein FLJ20035
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1510 - 313 normal brain , low expressed in gliomas Nakada
  • N-terminal 313-amino acid region of testican 3, with a 3-amino acid substitution at the COOH terminus
  • inhibitor of membrane-type matrix metalloproteinases (MT-MMPs)
  • - - 2168 - 436 normal brain but low expressed in gliomas Nakada
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   predominantly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one follistatin-like domain
  • one kazal-like domain
  • one EF -hand calcium-binding domain
  • one thyroglobulin type-I domain
  • HOMOLOGY
    interspecies ortholog to murine Spock3
    ortholog to rattus Spock3_predicted
    Homologene
    FAMILY Testican family proteins
    CATEGORY regulatory , secretory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • having metalloendopeptidase inhibitor activity
  • may be participaing in diverse steps of neurogenesis and inhibiting the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP
  • suppressing membrane-type 1 matrix metalloproteinase (MMP)-mediated MMP-2 activation and tumor invasion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Ca2+
    protein
    cell & other
    REGULATION
    repressed by SPOCK2, by binding to the COOH-terminal extracellular calcium-binding domain of N-Tes through its NH(2)-terminal unique domain
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    gliomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene N-Tes-Delta 122, which is resistant to testican 2, may have therapeutic potential as a barrier against glioma invasion
    Marker
    Therapy target
    ANIMAL & CELL MODELS