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FLASH GENE
Symbol SPOCK1 contributors: mct/npt - updated : 07-07-2008
HGNC name sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
HGNC id 11251
Location 5q31      Physical location : 136.310.987 - 136.835.018
Synonym name
  • testican-1
  • sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican)
    • Synonym symbol(s) TIC1, SPOCK, FLJ37170, TESTICAN, TICN1
    DNA
    TYPE functioning gene
    STRUCTURE 524.00 kb     10 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Map see IRF1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 4841 49 439 - Prenzel (2006)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear   highly
    Nervousbrain   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • CWCV and Kazal-like domains proteoglycan
  • osteonectin (SPARC)-like domain
  • thyroglobuline type 1 repeat
    • HOMOLOGY
    interspecies homolog to murine Spock1
    Homologene
    FAMILY
  • testican family proteins
    • CATEGORY adhesion , regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • multifunctional matricellular protein involved in cell-matrix interactions and might be involved in tumor pathogenesis and progression
  • may have a function related to protease inhibition in the blood
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text control of cell proliferation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    overexpression is significantly more frequent in pancreatic cancer than cancer of the papilla of Vater
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS