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FLASH GENE
Symbol SPNS2 contributors: mct - updated : 25-08-2011
HGNC name spinster homolog 2 (Drosophila)
HGNC id 26992
Location 17p13.2      Physical location : 4.402.128 - 4.443.228
DNA
TYPE functioning gene
STRUCTURE 41.10 kb     13 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 4349 - 549 - 2011 21084291
EXPRESSION
Rna function SPNS2 mRNA is abundant in lung and placenta and moderately expressed in many other tissues
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to zebrafish Spns2
Homologene
FAMILY
CATEGORY transport carrier
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • FTY720-P (a new class of immunosuppressors that has been approved as a novel oral therapeutic drug for multiple sclerosis) transporter in cells
  • can transport S1P analogues accumulated inside cells, but only transports phosphorylated sphingolipids
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • in zebrafish, Spns2 functioning as an S1P transporter regulates the migration of cardiac progenitors