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FLASH GENE
Symbol SPN contributors: mct - updated : 16-03-2012
HGNC name sialophorin (gpL115, leukosialin, CD43)
HGNC id 11249
Location 16p11.2      Physical location : 29.674.299 - 29.681.821
Synonym name
  • cell differentiation antigen CD43 (gp115), identified by antibodies G10-2, G19-1
  • Synonym symbol(s) CD43, LSI, GPL115, LSN, UN1
    DNA
    TYPE functioning gene
    STRUCTURE 7.53 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map pter - PRKCB1 - SPN - ITGAM - cen
    Physical map
    LOC283892 16p12.1 hypothetical gene supported by NM_017869; AK023827 LOC283895 16p12.1 hypothetical LOC283895 LOC388239 16 similar to nuclear pore complex interacting protein LOC388240 16 similar to MGC9515 protein LOC388241 16 similar to PI-3-kinase-related kinase SMG-1 isoform 2; lambda/iota protein kinase C-interacting protein; phosphatidylinositol 3-kinase-related protein kinase MGC5178 16p12.1 hypothetical protein MGC5178 LOC388242 16 similar to hypothetical protein BC011981 KIAA0220 16p12.1 KIAA0220 protein LAT1-3TM 16p12 LAT1-3TM protein LOC388243 16 similar to carbonic anhydrase VA, mitochondrial precursor; carbonic anhydrase V, mitochondrial; carbonic dehydratase SPN 16p11.2 sialophorin (gpL115, leukosialin, CD43) QPRT 16q13 quinolinate phosphoribosyltransferase (nicotinate-nucleotide pyrophosphorylase (carboxylating)) FLJ35681 16p12.1 hypothetical protein FLJ35681 ZG16 16p12.1 zymogen granule protein 16 KIF22 16p11.2 kinesin family member 22 MAZ 16p11.2 MYC-associated zinc finger protein (purine-binding transcription factor) LOC112476 16p12.1 similar to lymphocyte antigen 6 complex, locus G5B; G5b protein; open reading frame 31 MGC4606 16p12.1 hypothetical protein MGC4606 MVP 16p11.2 major vault protein CDIPT 16p12.1 CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) PSK-1 16p12.1 type I transmembrane receptor (seizure-related protein) KCTD13 16p11.2 potassium channel tetramerisation domain containing 13 LOC253982 16p12.1 hypothetical protein LOC253982 LOC124446 16p12.1 hypothetical protein BC017488 PSK 16p12.1 hypothetical protein BC017488 TAO1 16p11.2 hypothetical protein BC017488 HIRIP3 16q13 HIRA interacting protein 3 FLJ90652 16p12.1 hypothetical protein FLJ90652 DOC2A 16q13 double C2-like domains, alpha DKFZP434I2117 16p12.1 hypothetical protein DKFZp434I2117
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 6915 - 400 - 2004 15280197
    2 - 6871 - 400 - 2004 15280197
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
     spleen    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticneutrophil
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines myelomas
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three extracellular domains, an hydrophobic transmembrane segment (TM)
  • a phosphorylation site at Ser-76 (S76) within its cytoplasmic tail
  • a C terminal intracellular domain containing a number pf sites phosphorylated by protein kinase C
  • ectodomain of SPN is considered as a molecular barrier for cell adhesion, while the cytoplasmic domain has a binding site for Ezrin/Radixin/Moesin (ERM)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation
  • playing a role in the physicochemical properties
  • of the T-cell surface and in lectin binding
  • functions potentially as a signaling molecule, sensing extracellular cues and transducing intracellular signals that modulate T-cell function
  • its overexpression activates TP53 and suppresses colony formation due to induction of apoptosis
  • potential contributor to tumor development and the functional ARF-TP53 pathway is required for the elimination of cells with aberrant CD43 expression
  • highly glycosylated transmembrane protein that regulates T cell activation
  • generally serves as an antiadhesive molecule to attenuate neutrophil-endothelial interactions, but when E-selectin is expressed on endothelial cells, it also plays a proadhesive role as an E-selectin ligand
  • involved in the regulation of lymphocyte adhesion and activation
  • inhibitor for cell adhesion
  • regulates multiple T-cell functions, including T-cell activation, proliferation, apoptosis, and migration
  • SPN movement and regulation of T-cell migration can occur through an ERM-independent, phosphorylation-dependent mechanism
  • transmembrane sialoglycoprotein involved in cell adhesion, differentiation, and apoptosis
  • is the UN1 antigen, peculiarly expressed in fetal tissues and several cancer tissues, including leukemic T cells, breast, and colon carcinomas
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ezrin pradixin/moesin (ERM) proteins binding
  • ICAM1 (defective in WAS)
  • interacting with HIPK2 via the cytoplasmic domain
  • SPN interacts with BSG and ITGB2 in two distinct but similarly reorganized complexes
  • interaction with ezrin-radixin-moesin (ERM) proteins regulates T-cell trafficking and its phosphorylation (
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS